HMGCoA还原酶(HMGCoAreductase)是合成胆固醇的限速酶,存在于小胞体膜,催化合成甲基二羟戊酸(mevalonicacid),并生成体内多种代谢产物,称之为甲基二羟戊酸途径。细胞内胆固醇水平调节主要依赖于内因性胆固醇合成途径和LDL受体摄取细胞外胆固醇的外因途径两条。Goldstein和Brown阐明其抑制机制认为,细胞内Ch可作为HMGCoA还原酶...
例句In conjunction with the glutathione reductase/peroxidase system, NADPH maintains the sulfhydryl groups of globin in their reduced state. NADPH通过与谷胱甘肽还原酶/过氧化物酶系统结合,维持球蛋白巯基基团的还原态。 概述 概述 HMG-CoA还原酶(3-羟基-3-甲基-戊二酰辅酶A还原酶,正式缩写为HMGCR,是速率控制...
Simvastatin是一种常用的HMG-CoA Reductase抑制剂。Simvastatin是一种临床上用于降低胆固醇的药物,药品名称为Zocor。人体每日口服5~80mg Simvastatin,大约可以下调总胆固醇(Cholesterol)19~36%,下调LDL 26~47%,上调HDL8~16%,下调甘油三酯12~33%。 HMG-CoA Reductase的抑制剂通常被称为statins,中文名为他汀,常称作...
Noun1.HMG-CoA reductase- a liver enzyme that is responsible for producing cholesterol 5-hydroxy-3-methylglutaryl-coenzyme A reductase reductase- an enzyme that catalyses the biochemical reduction of some specified substance Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton Uni...
因所有 前院內 HMG-CoA Reductase Inhibitors Statins 皆有可能發生肌肉毒性之不良反 (Statins)降血脂藥物有 Lovastatin (Meva- 應,因此建議下列病人於接受 Statins 之降 ® ® cor ) 、Simvastatin(Zocor ) 、Pravastatin 血脂治療期間應定期監測任何肌肉毒性相 (Mevalotin® ® ) 、Fluvasatin...
HMG-CoA Reductase 目录号 CN120373 储藏条件 储存于-20℃ 形式 化合物粉末置于带盖冻存管中,排放于10×10冻存盒中 运输方式 冰袋或干冰冰盒运输 描述 1. 普思化合物库包含的产品精选于上千种来源独特的天然产物;2. 具有结构多样、来源多样、活性覆盖性广等特点;3. 提供产品的活性信息来自于世界各大期刊...
(redirected from HMG-CoA reductase i)Also found in: Thesaurus, Medical, Encyclopedia. in·hib·i·tor also in·hib·it·er (ĭn-hĭb′ĭ-tər) n. One that inhibits, as a substance that retards or stops a chemical reaction. American Heritage® Dictionary of the English Language,...
碧云天生物技术有限公司生产的Simvastatin (HMG-CoA Reductase抑制剂),▼▲产品编号产品名称产品包装产品价格S1868Simvastatin(HMG-CoAReductase抑制剂)10mg533.00元Simvastatin是一种
atherosclerosis. HMG-CoA reductase is thus the target of the widely available cholesterol-lowering drugs known collectively as the statins. HMG-CoA reductase is anchored in the membrane of the endoplasmic reticulum, and was long regarded as having seven transmembrane domains, with the active site ...
HMG-CoA reductase contains two domains: an eight-transmembrane spanning region that localizes the protein to the endoplasmic reticulum and a carboxy-terminal domain that projects into the cytosol and contains the catalytic activity (Figure 2). Degradation of HMG-CoA reductase is regulated, and the ...