HMGCoA还原酶(HMGCoAreductase)是合成胆固醇的限速酶,存在于小胞体膜,催化合成甲基二羟戊酸(mevalonicacid),并生成体内多种代谢产物,称之为甲基二羟戊酸途径。细胞内胆固醇水平调节主要依赖于内因性胆固醇合成途径和LDL受体摄取细胞外胆固醇的外因途径两条。Goldstein和Brown阐明其抑制机制认为,细胞内Ch可作为HMGCoA还原酶...
例句In conjunction with the glutathione reductase/peroxidase system, NADPH maintains the sulfhydryl groups of globin in their reduced state. NADPH通过与谷胱甘肽还原酶/过氧化物酶系统结合,维持球蛋白巯基基团的还原态。 概述 概述 HMG-CoA还原酶(3-羟基-3-甲基-戊二酰辅酶A还原酶,正式缩写为HMGCR,是速率控制...
Statins are inhibitors against HMG CoA reductase (HMGCR) that function to lower plasma cholesterol levels. Inhibition of HMGCR activity results in decreased levels of mevalonate and its downstream products that affect critical cell functions such as membrane integrity, cell signaling, protein synthesis, ...
网络释义 1. 还原酶 ...是作为竞争性抑制剂抑制肝脏细胞内羟甲戊二酰辅酶A还原酶(HMG-CoA reductase)活力, 限制HMG-CoA 向甲基二羟戊酸的 … www.bioon.com|基于4450个网页 2. 酵素 决定步骤酵素(HMG-CoA reductase)活性,而使mevalonic acid无法生成,以致间接无法合成胆固醇,进而达到降低胆固醇的 … ...
HMG-CoA还原酶活性/抑制剂筛选试剂盒(比色法)利用HMG-CoA还原酶反应消耗NADPH的特性,利用特异性探针,检测NADPH含量(OD 340 nm),NADPH含量的减少反应了酶活性.本试剂盒既可以测酶活性,又可以用来筛选HMG-CoA还原酶的抑制剂.
HMG-CoA Reductase Inhibitor产品规格:10mg发货周期:1~3天产品价格:询价本产品仅可用于科研实验,严禁用于其他非科研用途!Simvastatin是一种常用的HMG-CoA Reductase抑制剂。Simvastatin是一种临床上用于降低胆固醇的药物,药品名称为Zocor。人体每日口服5~80mg Simvastatin,大约可以下调总胆固醇(Cholesterol)19~36%,下调...
上海康朗生物科技有限公司生产的Lovastatin (HMG-CoA Reductase抑制剂),最新报价:542元/mg,Lovastatin(HMG-CoAReductase抑制剂)Lovastatin是一种常用的HMG-CoAReductase抑制剂。Lovastatin是一种
MCE 国际站:HMG-CoA Reductase 品牌:MedChemExpress (MCE) 概述:HMG-CoA 还原酶 (HMGCR) 是 HMG-CoA 转化为甲羟戊酸过程中胆固醇合成的限速酶。 HMGCR 存在于真核生物和原核生物中。系统发育分析揭示了两类HMG-CoA还原酶,真核生物和一些古细菌的I类酶以及真细菌和某些其他古细菌的II类酶。已知在真核生物和古...
Functional expression ofhuman HMG-CoA reductase in Saccharomyces cerevisiae: a system to analyse normaland mutated versions of the enzyme in the context of statin treatment. Wysocka-Kapcinska M,Lutyk-Nadolska J,Kiliszek M, et al. J ApplMicrobiol . 2009...
the reductase induce the expression of LDL receptors in the liver,which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. HMG-CoA reductase is thus the target of the widely available cholesterol-lowering drugs...