HMG-CoA Reductase,即HMG-CoA还原酶,也就是3-羟基-3-甲基戊二酸单酰辅酶A还原酶,催化甾醇和类异戊二烯生物合成的限速步骤。 在人类中,HMG-CoA Reductase是肝细胞合成胆固醇过程中的限速酶,催化生成甲羟戊酸,抑制HMG-CoA Reductase能阻碍胆固醇合成。因此,它是降低血清胆固醇水平的药物...
nitrate reductase 硝酸还原酶 nitrite reductase 亚硝酸还原酶 ribonucleotide reductase 核糖核苷酸还原酶 dihyrofolate reductase 二氢叶酸还原酶 相似单词 HMG CoA 【化】 β-羟-β-甲戊二酸单酰辅酶A; β-羟基-β-甲基戊二酸单酰辅酶A HMG abbr. 女王陛下政府,英王陛下政府 reductase n. [生化]还...
例句In conjunction with the glutathione reductase/peroxidase system, NADPH maintains the sulfhydryl groups of globin in their reduced state. NADPH通过与谷胱甘肽还原酶/过氧化物酶系统结合,维持球蛋白巯基基团的还原态。 概述 概述 HMG-CoA还原酶(3-羟基-3-甲基-戊二酰辅酶A还原酶,正式缩写为HMGCR,是速率控制...
网络释义 1. 还原酶 ...是作为竞争性抑制剂抑制肝脏细胞内羟甲戊二酰辅酶A还原酶(HMG-CoA reductase)活力, 限制HMG-CoA 向甲基二羟戊酸的 … www.bioon.com|基于4450个网页 2. 酵素 决定步骤酵素(HMG-CoA reductase)活性,而使mevalonic acid无法生成,以致间接无法合成胆固醇,进而达到降低胆固醇的 … ...
MCE 国际站:HMG-CoA Reductase 品牌:MedChemExpress (MCE) 概述:HMG-CoA 还原酶 (HMGCR) 是 HMG-CoA 转化为甲羟戊酸过程中胆固醇合成的限速酶。 HMGCR 存在于真核生物和原核生物中。系统发育分析揭示了两类HMG-CoA还原酶,真核生物和一些古细菌的I类酶以及真细菌和某些其他古细菌的II类酶。已知在真核生物和古...
the reductase induce the expression of LDL receptors in the liver,which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. HMG-CoA reductase is thus the target of the widely available cholesterol-lowering drugs...
1.抑制HMG-CoA还原酶 HMG-CoA还原酶是胆固醇合成酶系中的关键酶,他汀类药物通过对它的抑制作用从而使肝脏合成胆固醇受到抑制。洛伐他汀和新伐他汀口服需在体内激活才有生物活性。阿托伐他汀和吸立伐他汀口服吸收后即具有生物活性 [2] 。 2.增加低密度脂蛋白受体密度 他汀类药物可直接使肝脏LDL受体密度增加,也...
HMG-CoA Reductase; Hydroxymethylglutaryl-CoA Reductase来源:原核表达宿主:E.coli内毒素水平:<1.0EU/µg(LAL法测定)亚细胞定位:内质网腔预测分子量:30.0kDa实际分子量:30kDa(差异分析请参阅说明书)片段与标签:Ala638~Ala887 with N-terminal His Tag缓冲...
As the putative key enzyme of cholesterol synthesis in the intestine as well as in other tissues, gut HMG-CoA reductase has been studied extensively in recent years. Despite these efforts, both the cellular localization and the regulation of the enzyme are still controversial....
Noun1.HMG-CoA reductase- a liver enzyme that is responsible for producing cholesterol 5-hydroxy-3-methylglutaryl-coenzyme A reductase reductase- an enzyme that catalyses the biochemical reduction of some specified substance Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton Uni...