This hypothesis has been directly tested using a cDNA and an antibody for hMG-CoA reductase message and protein, respectively. In addition, since a decrease in cellular sterol upregulates the level of hMG-Co A reductase mRNA, we examined the possibility that estradiol's action on hMG-Co A ...
HMG-CoA reductase from microsomes of rats killed at noon and midnight has similar properties. Cycloheximide completely prevents the 5- to 10-fold rise in activity which occurs from 6 p.m. to midnight, suggesting that the rise in activity is due to synthesis of new enzyme. The effect of ...
Effects of isoenergetic high-carbohydrate compared with high-fat diets on human cholesterol synthesis and expression of key regulatory genes of cholesterol... cholesterol synthesis rate, and the messenger RNA (mRNA) concentrations of beta-hydroxy-beta-methylglutaryl coenzyme A (HMG-CoA) reductase, the...
VanaL.SmithandLynnG.BrentandM.SuzanneShabbotSDOSBiophysical JournalSmith, V. L., L. G. Brent, M. S. Shabbot, and R. E. Thompson. 1982. Regulation of microsomal HMG-CoA reductaseby enzyme-lipid interactions.Biophys.J . 37:42-44....
RPR 107393, a potent squalene synthase inhibitor and orally effective cholesterol-lowering agent: comparison with inhibitors of HMG-CoA reductase. J. Pharmacol. Exp. Ther. 281, 746–752 (1997). CAS PubMed Google Scholar Ahn, K. W. & Sampson, N. S. Cholesterol oxidase senses subtle ...
51 AMPK also inhibits cholesterol synthesis by inducing the inhibitory phosphorylation of the rate-limiting enzyme HMG-CoA reductase.52 In addition to the inhibition of lipid anabolism, AMPK activates lipid catabolism. AMPK increases FA uptake by controlling the translocation of FA transporter CD36 to...
Cloning and characterization of the gene encoding HMG-CoA reductase from Taxus media and its functional identification in yeast. Functional Plant Biology, 2004, 31: 73-81. [59] 曹小迎, 蒋继宏, 刘群等. 大戟甲羟戊酸途径关键酶基因hmgr的克隆与分析[J]. 武汉植物学研究, 2007, 25(2): 123- 126...
Mevalonateand 2-C-methyl-D-erythritol 4-phosphate(MEP) pathways are known to be responsible for biosynthesis of numerous isoprenoids.HMG-CoA reductase is arate-determining enzyme in mevalonate pathway, producing intermediates such asfarnesyl and geranylgeranyl pyrophosphates, which lead to by-products ...
Einarsson Regulation of HMG- CoA reductase in human liver B. Preiss (Ed.), Regulation of HMG-CoA Reductase, Academic Press, New York (1985), pp. 281-320 View PDFView articleGoogle Scholar 16 Brown M.S., J.L. Goldstein General scheme for regulation of cholesterol metabolism in mammalian ...
Preemptive HMG-CoA reductase inhibition provides graft-versus- host disease protection by Th-2 polarization while sparing graft-versus- leukemia activity. Blood 110, 4588–4598 (2007). 87. De Wit, D. et al. Preferential activation of Th2 cells in chronic graft- versus-host reaction. J. ...