To diagnose and treat a patient with hemophagocytic lymphohistiocytosis (HLH) is a challenge. Nevertheless, since the clinical course may be rapidly fatal and since the presentation may be variable, in particular for secondary HLH, it is important for clinicians in many medical fields to be aware...
Despite the name of the disease, hemophagocytosis isnotnecessary to diagnose HLH. It can be helpful – but it isn’t specific for HLH, and can be found in a lot of other inflammatory conditions. So to diagnose HLH, you need either an established molecular abnormality consistent with an HLH...
but the gist is that they believe they’ve made progress toward being able to more confidently diagnose kids with this variation. This could help those coming along to have more surety in knowing if a transplant is needed, so we’re hopeful it represents progress in some way. More on that...
Intensivists should be aware of the presentation of HLH in ICU setting especially masquerading as sepsis with multiorgan failure and every effort should be made to diagnose the condition with the help of bone marrow examination and histopathology. HLH continues to be a highly underdiagnosed condition...
ALL-055: Leukemia-HLH: An Egyptian Experience - More Questions, Less Answers - ScienceDirectleukemiaHLHviral infectionALLacute lymphoblastic leukemiaContext Leukemia-associated HLH in children is among the most difficult to diagnose, and challenging to treat. The overall survival is 50% to 60%; ...
Bone marrow histomorphological criteria can accurately diagnose hemophagocytic lym-phohistiocytosis. Haematologica 2018, 103, 1635–1641. [Google Scholar] [CrossRef] Henter, J.; Horne, A.; Aricó, M.; Egeler, R.M.; Filipovich, A.H.; Imashuku, S.; Ladisch, S.; McClain, K.; Webb, D...