HLA-DQ2 and HLA-DQ8 Are Expressed on So-Called Antigen-Presenting CellsFrits Koning
HLA-DQ2也就是HLA-DQB*02：01和02：02是高风险，还有HLA-DQ8也是高风险，
Area under curve (AUC) for HLA-DQ2/HLA-DQ8 (DQ2/DQ8) = 0.664, 95% CI: 0.632–0.696; for MSH5 = 0.729, 95% CI: 0.694–0.763 for MSH5 + HLA DQ2/HLA DQ8 (MSH5 + DQ2/DQ8 = 0.735, 95% CI: 0.700–0.769). Table 5. The sensitivity, specificity, accuracy (ACC), positive ...
namely those serologically recognized asHLA DQ2(90 to 95% of cases) andHLA DQ8(approximately 5% of cases). Fewer than 2% of celiac patients lack both HLA specificities; at the same time approximately one third of our “normal” population has one or the other marker. This means that the...
Celiac disease, HLA DQ2, HLA DQ8, epidemiologyStudies suggest that vitamin D may be involved in the pathogenesis of allergic disorders, asthma and decreased lung function. However, results are inconsistent and only few prospective studies have examined adults. The purpose of this study was to ...
就如同欧美人携带特定基因型(如HLA-DQ2/DQ8)更易触发IgE介导的过敏反应,而东亚人群相关基因分布显著不同。同时,我们饮食习惯夜有所不同。我们看美剧的时候,经常看到他们吃早餐的时候,就会涂抹花生酱,然后经常喝牛奶,用牛奶泡麦片等等,以这种高蛋白、加工食品为主。而我们则主要是以植物性饮食为主,过敏原接触...
prospectively followed 6,403 children who had the HLA haplotype DR3–DQ2 or DR4–DQ8 from birth. HLA haplotype DR3–DQ2 conferred a high risk of developing coeliac disease autoimmunity and coeliac disease in early childhood, particularly in those children who were homozygous....
All Special IssuesAdvances in Biological Activities and Application of Plant Extracts, 2nd EditionAdvances in Food Processing Technologies: Enhancing Quality, Safety, and SustainabilityAdvances in Wine, Brewing, Analysis and Grape-Derived ProductsAnti-Oxidants in Food: The Significance of Characterisation, ...
In HLA-DQ2.5 associated CeD, most patients respond to DQ2.5-glia-α1a, DQ2.5-glia-α2, DQ2.5-glia-ω1, and DQ2.5-glia-ω2 epitopes (5), whereas most patients expressing HLA-DQ8 respond to DQ8-glia-α1 (6). Hence, these epitopes are termed immunodominant epitopes. T cells reactive...
[1]抗HLA-DQ2.5抗体,其对HLA-DQ2.5具有结合活性,并且对HLA-DQ8基本不具有结合活性。 [2][1]所述的抗体,其中所述抗体对与谷蛋白肽的复合物的形式的HLA-DQ2.5(HLA-DQ2.5/谷蛋白肽复合物)具有结合活性。 [3][2]所述的抗体,其中所述谷蛋白肽是由以下各项组成的组中的至少一个、两个、三个、四个、五个...