HLA-DQ2 and HLA-DQ8 Are Expressed on So-Called Antigen-Presenting CellsFrits Koning
Presents a letter to the editor about the association of the human leukocyte antigen DQ2 and/or DQ8 with celiac disease-specific autoantibodies to tissue transglutaminase in families with thyroid autoimmunity.American Journal of Gastroenterology (Springer Nature)Badenhoop...
HLA-DQ2.2 carriers have an inconsequential risk of developing CD. In contrast, approximately 20–30% of the healthy Caucasian population is HLA-DQ2 positive. A gender-specific distribution of HLA alleles has been described: female patients with celiac disease are infrequently DQ2.5/DQ8-negative. ...
Celiac disease, HLA DQ2, HLA DQ8, epidemiologyStudies suggest that vitamin D may be involved in the pathogenesis of allergic disorders, asthma and decreased lung function. However, results are inconsistent and only few prospective studies have examined adults. The purpose of this study was to ...
现在可以搜索hla分型查看HLA-DQB了，HLA-DQ2也就是HLA-DQB*02：01和02：02是高风险，还有HLA-DQ8...
Type 1 diabetes mellitus is strongly associated with HLA-DQ8 in humans and I-A g7 in the NOD mouse. The disease is characterized by loss of tolerance to auto-antigens such as GAD, insulin, and the protein tyrosine phosphatase-like molecule, IA-2. We identified T cell epitopes on the in...
HLA-II包括HLA-DP、HLA-DQ、HLA-DR,其中DRBl位点809个,DRB3位点52个,DRB4位点14个,DRB5位点19个,DQBl位点55个,DPBl位点112个;HLA-II存在于B细胞、巨噬细胞、树突状细胞和活化T细胞中。HLA-III为补体系统(由20种不同的血清蛋白组成的多成分系统),包括C2和C4位点,存在于血清中。
HLA-DQ8基因编码了一种特定的HLA-DQ亚型,它是由HLA-DQA1*03和HLA-DQB1*03:02两个等位基因组成。 HLA-DQ8基因型与自身免疫性疾病的发病风险增加有关。例如,它与1型糖尿病、乳糜泻和类风湿性关节炎等疾病的发病风险增加相关。HLA-DQ8基因型也被认为与一些药物过敏反应的易感性有关。 HLA-DQ8基因型的检测可以...
Results Twenty-one patients (60 %) carried HLA-DQ2 or DQ8, twice the frequency of the general population ( P <0.001). In particular DQ2 was overrepresented ( P =0.013). Gender, age, disease stage, histopathological grade, or multifocality of primary tumor did not differ between patients ...
HLA-DQ molecule can be correlated, in immunological terms, with sub-optimal antigen peptide lodging, impaired self-antigen presentation in thethymusand, consequently, non-efficient negative selection of self-reactive T-cell clones or reduction of the positive selection ofregulatory T cells[47,49,50...