Therefore the use of radiologic imaging and intraoperative enteroscopy for diagnosis should...doi:10.1016/S0016-5085(12)61058-0Jamma, ShailajaKupfer, SoniaPaski, ShirleySemrad, Carol E.Elsevier Inc.Gastroenterology
HLA-DQ2.2 carriers have an inconsequential risk of developing CD. In contrast, approximately 20–30% of the healthy Caucasian population is HLA-DQ2 positive. A gender-specific distribution of HLA alleles has been described: female patients with celiac disease are infrequently DQ2.5/DQ8-negative. ...
The large majority of CD patients express HLA-DQ2 and the remainder usually are HLA-DQ8 positive. HLA-DQ2 and -DQ8 are HLA class II molecules that bind and present peptides to CD4+ T cells. HLA-DQ molecules are heterodimers consisting of an α and a β chain. Many different HLA-DQ ...
Piancatelli等使用聚合酶链式反应-序列特异性引物(Polymerasechainreaction-sequence-specificprimer,PCR-SSP)对HLA进行基因分型发现DQ2.2和DQ2.5在摩洛哥CD患者出现的频率较正常对照高,且差异具有统计学意义,而DQ8在摩洛哥CD患者和正常对照之间出现频率差异无统计学意义[3]。 与HLA-DQ2.5/X(X指等位基因位点为非DQ2.5)...
HLA-DQ8基因编码了一种特定的HLA-DQ亚型,它是由HLA-DQA1*03和HLA-DQB1*03:02两个等位基因组成。 HLA-DQ8基因型与自身免疫性疾病的发病风险增加有关。例如,它与1型糖尿病、乳糜泻和类风湿性关节炎等疾病的发病风险增加相关。HLA-DQ8基因型也被认为与一些药物过敏反应的易感性有关。 HLA-DQ8基因型的检测可以...
就如同欧美人携带特定基因型(如HLA-DQ2/DQ8)更易触发IgE介导的过敏反应,而东亚人群相关基因分布显著不同。同时,我们饮食习惯夜有所不同。我们看美剧的时候,经常看到他们吃早餐的时候,就会涂抹花生酱,然后经常喝牛奶,用牛奶泡麦片等等,以这种高蛋白、加工食品为主。而我们则主要是以植物性饮食为主,过敏原接触...
HLA-DQ2也就是HLA-DQB*02：01和02：02是高风险，还有HLA-DQ8也是高风险，
A. 强直性脊椎炎与B27:正确关联,强直性脊柱炎患者HLA-B27阳性率显著升高。 B. 类风湿关节炎与DR4:正确,HLA-DR4(尤其是DRB1*04)与类风湿关节炎易感性密切相关。 C. Reiter病与B27:正确,反应性关节炎(原Reiter病)与HLA-B27关联明确。 D. 1型糖尿病与DQ8:正确,HLA-DQ8(DQB1*0302)是1型糖尿病的重要遗传风...
HLA-B27 HLA-DQ2DQ8 HPV(附翻译)HLA-B27 Definition. HLA-B27 findet sich bei etwa 8 % der kaukasischen Bevölkerung auf der Oberfläche von Leukozyten und ist stark mit dem Vorkommen des Morbus Bechterew (ankylosierende Spondylitis), aber auch anderer Störungen mit einem Autoimmun...
This means that the demonstration of being DQ2 and/or DQ8 positive has a strong negative predictive value, but a very weak positive predictive value for the diagnosis of celiac disease. With these limitations, it may prove useful to exclude celiac disease in subjects on a gluten-free diet, ...