The HLA-DQ2 gene dose effect in celiac disease is directly related to the magnitude and breadth of gluten-specific T cell responses. Proc Natl Acad Sci USA. 2003;100(21):12390-5.Vader W, Stepniak D, Kooy Y, Mearin L, Thompson A, van Rood JJ, Spaenij...
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Figure 59.4.HLA association in celiac disease. The majority of celiac disease patients carry the HLA-DQ2.5 molecule, which can be encoded incisor intranspositions.Most of the remaining patients express HLA-DQ8 whereas the rest of the celiac disease patients express HLA-DQ2.2 or HLA-DQ7.5. The ...
To explore the basis for specific recognition of the homologous epitopes, we performed T-cell proliferation assays with amino acid–substituted epitopes, undertook single-cell TCRαβ-gene sequencing, and solved the crystal structures of HLA-DQ2.5 complexed with either DQ2.5-glia-α1a or DQ2.5-...
Coeliac disease is an inflammation of the small intestine, occurring in genetically susceptible individuals triggered by the ingestion of gluten. Human Leukocyte Antigens (HLA) DQ2 and DQ8 gene have been identified as key genetic factors in coeliac disease as they are presented in almost 100聽% ...
Patients with type 1 diabetes (T1D) are at increased risk for developing celiac disease (CD). The aim of the study was to assess the usefulness of celiac-specific human leukocyte antigen (HLA) haplotype and the rs3130484 variant of MSH5 gene, a previousl
Gold nano- particle fluorescent molecular beacon for low-resolution DQ2 gene HLA typing. Anal Bioanal Chem. 2012;402(3):1001-9.Beni V, Zewdu T, Joda H, Katakis I, O’Sullivan CK. Gold nanoparticle fluorescent molecular beacon for low-resolution DQ2 gene HLA typing. Anal Bioanal Chem. ...
GENE FREQUENCYSerologic markers, HLA-DQ2 haplotype, andclinical features suggestive of celiac disease werestudied to assess their diagnostic value in amulticentric study to detect celiac disease in 675first-degree relatives of 227 celiac probands. SerumIgA-class anti-endomysium and IgA -class anti-...
A B-LCL expressing the DQ(alpha 1*501, beta 1*0301) heterodimer was transfected with the DQB1*0201 gene, or with DQB1*0201 genes altered by site-directed mutagenesis. Surface expression of the wild-type or mutated DQ(alpha 1*0501, beta 1*0201) heterodimers was observed in the transfect...
Partanen,J.The HLA-DRB4 gene does not explain genetic susceptibility in HLA-DQ2-negative celiac disease (letter)[J].2000,3(3).Partanen J (2000) The HLA-DRB4 gene does not explain genetic susceptibility in HLA-DQ2-negative patients. Immunogenetics 51:249-250...