HLA-DQ2基因与自身免疫疾病的关系已经得到了广泛的研究。研究表明,HLA-DQ2基因的存在与糖尿病、类风湿性关节炎、自身免疫性甲状腺疾病等多种自身免疫疾病的发病风险有关。尤其是在乳糜泻病人中,HLA-DQ2基因的表达率高达90%以上。 乳糜泻是一种常见的自身免疫性疾病,它的发病与HLA-DQ2基因密切相关。研究表明,HLA...
HLA-DQ AntigensIntestine, SmallCD4阳性T淋巴细胞乳糜泻麦醇溶蛋白HLA-DQ抗原小肠The authors have analysed gliadin specific, CD4+ T cells isolated from small intestinal biopsies of 23 adult coeliac disease patients (20 on a gluten-free diet and three untreated) and nine control patients. The ...
and interestingly, TGF-β suppresses TGase 2 expression in that system. Therefore, it was suggested that the increased expression of TGase 2 leading to pathogenesis of celiac disease in genetically predisposed individuals (HLA-DQ2+) could be due to...
分别构建HLAa链和β链表达载体，生产可溶性MHC II类分子HLA-DQ2.5:33mer(LQLQPFPQPELPYPQPELPYPQPELPYPQPQPF)复合物，用于抗体开发免疫原，筛选原（33mer麦醇溶蛋白肽含有多个致病表位，例如DQ2.5-glia-α1a、DQ2.5-胶质细胞-α2 和 DQ2.5-胶质细胞-α1b）。单B细胞兔单抗筛选：使用重组HLA-DQ2.5:3...
HLADQ2阳性者接种HBsAg/ASO4乙肝 疫苗的免疫应答 HCVIRES的转译.另外,在强力霉素控制 条件下诱导的NS4A抑制了Hela细胞的增 殖.总之,HCVNS4A和NS4B蛋白质有转 译抑制作用的效能,这种新功能参与HCV 的感染,并有助于其在宿主细胞中存活. [KatoN.JMedVirol,2002,66(2):187 ...
HLA-DQ2也就是HLA-DQB*02：01和02：02是高风险，还有HLA-DQ8也是高风险，
Celiac disease, HLA DQ2, HLA DQ8, epidemiologyStudies suggest that vitamin D may be involved in the pathogenesis of allergic disorders, asthma and decreased lung function. However, results are inconsistent and only few prospective studies have examined adults. The purpose of this study was to ...
HLA DR3- DQ2 is double serotype that specifically recognizes cells from individuals who carry a multigene HLA DR, DQ haplotype. Certain HLA DR and DQ genes have known involvement in autoimmune diseases. DR3-DQ2, a multigene haplotype, stands out in prominence because it is a factor in ...
就如同欧美人携带特定基因型(如HLA-DQ2/DQ8)更易触发IgE介导的过敏反应,而东亚人群相关基因分布显著不同。同时,我们饮食习惯夜有所不同。我们看美剧的时候,经常看到他们吃早餐的时候,就会涂抹花生酱,然后经常喝牛奶,用牛奶泡麦片等等,以这种高蛋白、加工食品为主。而我们则主要是以植物性饮食为主,过敏原接触...
HLA-DQ2 and/or HLA-DQ8 haplotypes were present in 84.21% of T1D patients and in all CD subjects and were significantly higher in both of these groups compared with controls (Table 3). The HLA-DQ8 haplotype was significantly more frequent (p = 5.98 × 10−20) in the T1D than in ...