Background and AimsGenes encoding HLA DQ2/DQ8 are associated with celiac disease (CD) and testing for their presence has high negative predictive value for the diagnosis. The aim of this study was to assess the role of HLA typing in symptomatic individuals in whom the diagnosis of CD is ...
4 which generally are much better recognized by the T cells after deamidation by the enzyme transglutaminase 2 (TG2).5,6 The strong HLA association of celiac disease with HLA-DQ2 and HLA-DQ87 and selective recognition of gluten peptides in the context of the very same HLA molecules by ...
Remarkably, higher concomitant positivity of DQ2(+) and DQ8(+) was found in patients presenting with CD and type 1 DM coexistence. Conclusion: Genetic tests are used for the exclusion of CD disease, rather than diagnosis of. The importance of genetic te...