Background and AimsGenes encoding HLA DQ2/DQ8 are associated with celiac disease (CD) and testing for their presence has high negative predictive value for the diagnosis. The aim of this study was to assess the role of HLA typing in symptomatic individuals in whom the diagnosis of CD is ...
A crystal structure of TRAV4/TRBV20-1 TCR–HLA-DQ2.5–DQ2.5-glia-α1a complex uncovered that the TRAV4 bias is a consequence of interactions between the germ line–encoded TCR residues and HLA-DQ2.5 (10). Crystal structures of TRAV26-2/TRBV9-TCR–HLA-DQ8–DQ8-α1-gliadin and TRAV...
Remarkably, higher concomitant positivity of DQ2(+) and DQ8(+) was found in patients presenting with CD and type 1 DM coexistence. Conclusion: Genetic tests are used for the exclusion of CD disease, rather than diagnosis of. The importance of genetic te...
power for CD in the group of T1D, but after p-value correction for multiple hypothesis testing using the Benjamini–Hochberg algorithm p-values for all combinations (MSH + HLA-DQ2, MSH + HLA-DQ2.5, and MSH + HLAQD2/HLA-DQ8), this did not achieve statistical significance (p = 0.06)....