HLA - B * 1502 allele has been identified as FDA taking card before the West, to the point that the current general Classic is SSP - PCR, but its time-consuming, cumbersome, expensive, to the detriment of the patient quickly to give a medication guide, but also the ability of the pro...
[7] Lonjou C, Thomas L, Borot N, et al. A marker for Stevens-Johnson syndrome: ethnicity matters. Pharmacogenomics J. 2006, 6(4):265-8. [8]. Man CB, Kwan P, Baum L, et al. Association between HLA-B*...
山东 济南 250033; 山东省药品不 良反应监测中心 ,山东 济南 250013 ) 摘要 :对近几年来各国学者对 HLA—B*1502 等位基 因与抗癫痫药物致不同种族严重皮肤反应关系的研究进行了综 述 ,并对可能的机制进行初步分析 ,以期对合理使用抗癫痫药物 ,预防和减少严重不良反应提供思路。
aif testing for the presence of the hla-b*1502 allele should be perfomed high-resolution hla-b1502 genotyping is recommended 如果测试对于hla-b *1502等位基因的出现应该要求perfomed被推荐的高分辨率hla-b1502 genotyping的冰[translate]
(PCR-SSP) method in 19 Han subjects who had carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis,90 carbamazepine tolerant controls,and 80 healthy individuals.Results:The frequency of HLA-B*1502 allele in SJS/TEN patients was significantly higher than that in carbamazepine-...
B1502alleleisassociatedwithearbamazepine.inducedcutaneousadverse reactionsinHanpeopleofChinamainland.【Methods】HLA—B1502allelegenotypingwasperformedbyapolymerasechain reaction—sequencespecificprimers(PCR—SSP)methodon48HanChinesesubjectswhohadcarbamazepine—inducedcutaneous adversereactions,including9severecutaneous...
Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with HLA-B*1502 allele in Thai population. PURPOSE: Previous studies found a strong association between HLA-B*1502 and carbamazepine (CBZ)-induced Stevens-Johnson syndrome (SJS) in Han Chinese, but ... C Locharernkul,J ...
The purpose of this study is to examine the association of HLA-B*1502 allele with CBZ-induced SJS/TEN in the mainland Han Chinese population. HLA-B*1502 ge
1502allelebeforeprescribingcarbamazepine KEYWORDS:carbamazepine;severeepispasis;HLAB * 1502 卡马西平是临床上用于治疗癫痫、三叉神经痛和舌咽神 经痛、治疗神经原性尿崩症、躁狂抑郁症等疾病的常用药物。 其常见不良反应主要有:视力模糊、复视、头晕、乏力、恶心、 呕吐等 [1] ,偶见过敏反应、心律失常、肝损害、血...
一种用于检测hlab*1502等位基因的引物组及试剂盒 A method for detecting hla-b * 1502 allele primer set and kit 本发明提供了一种用于检测HLAB*1502等位基因的PCR扩增引物组和Taqman探针,包含两对根据HLAB*1502特异性序列设计的引物及相应两条探针,还包含一对用于筛除HLAB*1502假... 陈炤源,王浩,张金涛,...