The immunogenetics research and clinical communities are undergoing a revolution in the way that Human Leukocyte Antigens (HLA) alleles are typed, thanks to the introduction and increasing acceptance of next-generation sequencing into laboratory practice. With the ability to sequence all exons of each...
HLA-DRB1*01:02 was also significantly associated with FEV1 (p = 0.04) and oxygen saturation (p = 0.02), and the FEV1/FVC ratio was higher in HLA-DRB1*15:01-positive patients (p = 9 × 10−3). Conclusion We report an association among HLA-DRB1 alleles, COPD risk and pulmonary ...
several predictors have shown impressive performance on binding affinity. However, the decisive MHC residues and their relation to the selection of binding peptides are still unrevealed. Here, we connected HLA alleles with binding motifs via our deep learning-based framework, MHCfovea. MHC...
HLA alleles may serve as a tool to discriminate atypical type 2 diabetic patients AIM: To investigate whether the presence of human leukocyte antigen(HLA) marker could add new information to discriminated atypical diabetic type 2 patient... - 《World Journal of Diabetes》 被引量: 0发表: 2014...
HLA class I genotype is a major determinant of the outcome of HIV infection, and the impact of certain alleles on HIV disease outcome is well studied. Recent studies have demonstrated that certain HLA class I alleles that are in linkage disequilibrium, such as HLA-A*74 and HLA-B*57,...
The stratification of the cohorts by biological sex led to the identification of HLA alleles with a sex-specific effect; the same allele might be indifferent, protective or of risk, in one or the other sex (Table 2), or even non-significant in the whole population (see HLA-C*12 or *15...
目的:通过对中国人群HIV-1感染典型进展者(Typical progressors,TP)和长期不进展者(Long-term nonprogressors,LTNP)HLA-B等位基因的分布频率的研究,探讨中国人群HLA-B等位基因与HIV-1感染者疾病进程的关系。 更多例句>> 4) HLA-DRB1 allele HLA-DRB1等位基因 1. Association of HLA-DRB1 alleles with vitiligo...
HLA等位基因 6) HLA-B alleles HLA-B等位基因 1. Objective:To investigate the association of Chinese HIV infection with HLA class Ⅰ-B alleles and to analyze the correlation ofHLA-B alleleswith disease progression of HIV infection. 目的:通过对中国人群HIV-1感染典型进展者(Typical progressors,TP)和...
Based on these results, we speculate that HLA-DRB1 alleles are associated with the susceptibility to sporadic PD in Chinese Han population, among them HLA-DRB1*0301 is a risk allele while the effect of HLA-DRB1*0406 deserves debate. 展开 ...
Three novel HLA alleles HLA‐A*31:212, HLA‐B*50:01:20 and HLA‐C*03:593 alleles detected during routine next generation sequencing. A Ananeva,S Nizamov,O Gusev,... - HLA 被引量: 0发表: 2022年 Characterization of the novel alleles: HLA-A*31:212, HLA-B*50:01:20 and HLA-C*03...