The MHC Diversity in Africa Project (MDAP) Pilot - 125 African high resolution HLA types from 5 populationsThe major histocompatibility complex (MHC), orhuman leukocyte antigen (HLA) in humans, is ahighly diverse gene family with a key role in immune response to disease; and has been ...
Figure 1. HLA solution from Nanodigmbio. A.HLAtyping Panel v1.0 is based on the reference genome exon probes, supplemented with polymorphic probes according to the HLA database, to achieve effective capture of all types;B.HLAtyping Panel v2.0 can cover all known reference sequences in the l...
The human leukocyte antigen (HLA) system (the major histocompatibility complex [MHC] in humans) is an important part of the immune system and is controlled by genes located on chromosome 6. It encodes cell surface molecules specialized to present antigenic peptides to the T-cell receptor (TCR)...
Melanoma and renal-cell carcinoma (RCC) are generally considered to be relatively immunogenic tumor types in humans. In the case of melanoma, many major hi... N Brouwenstijn,B Gaugler,KM Krüse,... - 《International Journal of Cancer》 被引量: 289发表: 1996年 Identification of circulating ...
Responses may be more likely when there is a close match between the HLA molecules in the theraccine and the patients' own molecules. Alternatively, certain types of HLA class I molecules present in the patients may facilitate rejection of autochthonous melanomas by efficiently presenting melanoma-...
In humans, it is known as the hu- man leukocyte antigen (HLA) system and is located within a 3.6 Mb region on chromosome 6 (6p21.3) [3–5]. This region contains roughly 220 genes, which can be di- vided in HLA-like coding genes and non-HLA coding * Correspondence: josemgizarzu...
151K What is a Phenotype? Learn the phenotype definition, what phenotype means in genetics, and some common phenotype examples in humans and other organisms. Related to this QuestionThe genes for A and B blood antigens are inherited as autosomal codominant alleles. Explain what this means. Wha...
In humans, among all the factors needed for CD8 + T lymphocytes to initiate an immunogenic reaction, the critical gatekeeping step is the availability of peptides bound by human leukocyte antigen (HLA) class I molecules; this phenome has the potential for many clinical applications, such as...
HLA cross-matching is important in transplantation to avoid transplant rejection. The HLA-DRB1 locus is also commonly associated with disease susceptibility, for example rheumatoid arthritis, Type I diabetes mellitus and ankylosing spondylitis are all associated with specific HLA types (Choo, 2007). ...
HLA types in Japanese patients with primary hypothyroidism were analyzed to see whether those with blocking-type TSH receptor antibody (TSH-R BAb M) differ... D Inoue,K Sato,H Sugawa,... - 《Journal of Clinical Endocrinology & Metabolism》 被引量: 35发表: 1993年 SJÖGREN'S SYNDROME Sjg...