It is still a major challenge to identify the functional SNPs in a disease-related gene. This work explored how SNPs mutations in HLA-DRB1 gene could affect renal transplantation rejection. This study was carried out in Ahmed Gasim Hospital, Renal Dialysis Center during the period, from ...
revealing differential expression of PSMB9, HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQA1, HLA-DQB1, and HLA-DRB1 in immune cells. The present study pinpointed phosSNPs within susceptibility genes for JDM and unraveled the intricate relationships among these SNPs, gene expression levels, and JD...
MHC Class II: HLA-DRB1, Shared Epitope Hypothesis, and Rheumatoid Arthritis (RA) Rheumatoid arthritis (RA) is a common chronic systemic autoimmune disease, which primarily presents with a symmetrical polyarthritis and has a prevalence of 0.5–1% worldwide [118]. Although the exact pathogenesis of...
Whereas we found no correlation between HLA class II IMM burden and the number of HLA class II heterozygous alleles for the HLA-DPA1, DPB1, DQA1, DQB1, or DRB1 genes (NSCLC cohorts: Spearman’s rho = −0.03, P = 0.71; melanoma cohorts: Spearman’s rho = 0.08, P = 0.39), the ...
the DRB1*15:01 allele, an important risk factor for multiple sclerosis, was introduced into the European gene pool by steppe herders and maintained afterwards [6,14]. The same trend appears to apply to DQB1*06:02 that forms a haplotype with DRB1*15:01 [82] and was also not present in...
B*44 allotypes tended towards weak CD8 T cell responses (Jing et al.2012; Koelle et al.2003; van Velzen et al.2013). While no direct associations with HSV-1 and these alleles have been found, theA*33:03-B*44:03-DRB1*13:02haplotype is associated with PHN (Sato et al.2002; Sato...
摘要: 目的:研究生命脆弱年龄健康人群中15个特定STR座位(CSFIPO,D7S820,D8S1179,D21S11,D2S1338,D3S1358,D13S317,D16S539,TH01,D18S51,D19S433,TPOX,VWA,D5S818,FGA)和HLA(HLA-A,B,DRB1)基因多态性的分布特点. 方法:选取年龄为50～70... 查看全部>>关键词:...
As an example, HLA-H (also known as HFE) is a protein implicated in iron metabolism: mutations in this gene are responsible for most cases of hereditary hemochromatosis, a disease of iron overload [9]. Table 1 Summary of non-classical HLA-I molecules (HLA-E, F and G), their ...
3.4. Association of HLA-DRB1 and -DQB1 allele frequencies with AIP subtypes AIP type 1 and AIP type 2 patients showed a strong enrichment of homozygous HLA-DQB1 gene variants (AIP type 1: OR = 3.59, 95%CI 1.88–6.93, p < 0.001; AIP type 2: OR = 3.67, 95%CI 1.44–9.63, p < ...
The typing of HLA-DRB1 and -DQB1 was performed by using PCR-SSP low resolution method. Results Allele frequencies of HLA-DRB1 and HLA-DQB1 did not differ between boys with cryptorchidism and control boys. However, weakly significant differences in DRB1*04 (p corrected = 0.0475) and DQB1*...