Solomon et al (Human Immunology 34: Suppl.1:45 (1992) claimed that the expression of HLA-DR3 gene in Afro-American renal recipients was beneficial for the graft survival. The present study was undertaken to address this issue. A retrospective analysis of the SEOPF multicenter database on ...
(P<0. 05).Conclusion:HLA—DR3 couldbe 山esusceptiblegeneofAD,whileHLA—DR6couldbetheresistantgeneofAD.Theresultsindicatethatpeoplewith HLA—DR3arereliabletoAD,whilepeoplewithHLA—DR6arenot.Itissuggestedthatthespecificimmunoreactivitytomite, whichisinducedbytheADpatientswithHLA-DR3,mighttrigerthe...
HLA-II类基因主要经典型由DP、DQ、DR三个亚区构成,主要分布于B细胞、单核-巨噬细胞和树突状细胞表面,参与外源性抗原的提呈和免疫调节。HLA-III类基因位于HLA-I和类HLA-II类基因之间,且多数参与炎症反应,大多数功能不明[3]。HLA的功能有...
II类区域对应 HLA-DR、-DQ和 -DP基因等,编码 α 链基因 (A1) 和β 链基因 (B1)。α链和 β链配对形成功能性HLA分子。大多数个体携带额外的DRB基因 (DRB3 或 DRB4 或 DRB5),该基因编码可能与α链配对的不同β链。 III 类区域,其中的基因编码补体系统蛋白质和 TNF 家族基因。
Process for detecting HLA-DR3 genetype of AD patients by employing PCR techniqueThe invention relates to a method for detection of HLA-DR3 genotype of AD sufferers by means of PCR technology employing the denaturation, annealing, extension, circulation of the DNA reagent of the AD suffer to ...
结果证实多因子MTB特异性细胞上的HLA-DR在鉴别ATB和LTBI方面的表现优良。使用44%为阈值时,TNF-α+IL-2+细胞上的HLA-DR灵敏度为90.91%(95%CI,72.19-97.47%),特异性为68.97%(95%CI,50.77-82.73%)。表 3总结了验证队列中MTB特异...
HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 enc...
AIM: To assess the rigorous relationship between human leukocyte antigens (HLA)-DR alleles and outcomes of hepatitis B virus (HBV) infections by means of m... ZH Yan,Y Fan,XH Wang,... - 《World Journal of Gastroenterology》 被引量: 62发表: 2012年 Relationship between HLA-DR gene polymo...
Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They therefore have a critical role in the initiation of the immune response.HLA and ...