早期研究发现,中国人群中DRB1等位基因中的HLA-DR4亚型(0405)可能对IDDM有易感作用,近期人们研究认为HLA-DRB1*0301、DRB1*0901也具有易感性,而HLA-DR*0403、HLA-DR*0406具有保护作用,且HLA-DR*0403能够保护具有高危性的HLA-DR3/DR4杂合子不发生IDDM。HLA-DR4的亚...
模型中HLA风险基因指:HLA-DRB1*03,*04;DQB1*0302(即上述DR3、DR4和DR3/4-DQ8单倍型); HLA保护基因指:HLA-DQB1*0602。 可以看到,表1报告的基因型为DRB1*04:01-DQB1*03:02;DRB1*03:01-DQB1*02:01,是模型所指的HLA风险基因(DR3/4-DQ8单倍型),并且未携带保护...
1型糖尿病是一种由遗传和环境相互作用引发的疾病,遗传因素中与疾病最相关的是HLA基因(主要是DR、DQ基因)。 既往1型糖尿病也被称为青少年儿童糖尿病,因为研究表明发病高峰集中在这个年龄段。 但研究发现1型糖尿病可发生在任何年龄段,且近几年国内外成年起病的患者比以往有所增加。翁建平教授团队2018年的流行病学研...
diabetesjuvenile (type 1)DR3DR4DR17DR18 fatty liver (type 2)DR8 encephalomyelitisrabies vaccine-inducedDR17 encephalopathyacute necrotizingDR52 epilepsychildhoodDR5 infantile/spasmDR17 heart diseaserheumaticDR16 hepatitisautoimmuneDR2DR4DR17 primary biliary cirrhosisDR2DR8 ...
We describe the relation of HLA-DR3 and DR4 antigens to the 14-year incidence and progression of diabetic retinopathy and macular edema in this cohort. Design A population-based cohort study. Participants A probability sample of male and female patients receiving primary care for diabetes in 11...
基因别名:CD74; DHLAG; DR-4; DR4; DRB1; DRB4; DRw10; HLA-DR1B; HLA-DR3B; HLA-DR4B; HLA-DRA; HLA-DRA1; HLA-DRB; HLA-DRB1; HLA-DRB3; HLA-DRB4; HLA-DRB5; HLADG; Ia-GAMMA; II; MLRW; SS1 UniProt ID:(Human) P04233,(Human) P01903,(Human) Q4PRC3,(Human) Q7YQ62,...
基因别名: CELIAC1; DPB1; DR-4; DR4; DRB1; DRB4; DRw10; HLA-DP; HLA-DP1B; HLA-DPB; HLA-DPB1; HLA-DQB; HLA-DQB1; HLA-DR1B; HLA-DR3B; HLA-DR4B; HLA-DRA; HLA-DRA1; HLA-DRB; HLA-DRB1; HLA-DRB3; HLA-DRB4; HLA-DRB5; IDDM1; MLRW; SS1 UniProt ID: (Human)...
Association of IA-2 autoantibodies with HLA DR4 pheno- types in IDDM. Diabetologia 39: 1223–1226. 8. ROEP, B. et al. 1996. HLA-associated inverse correlation between T cell and antibody responsiveness to islet autoantigen in recent onset insulin-dependent diabetes melli- tus. Eur. J. ...
百度试题 结果1 题目与胰岛素依赖型糖尿病相关的是: ★★ A. HLA-DR3/DR4 B. HLA-DR5 C. HLA-B7 D. HLA-B27 E. HLA-DQ 相关知识点: 试题来源: 解析 A 反馈 收藏
The frequency of HLA-A-B and DR antigens as well as the Bf and C4 allotypes have been investigated in insulinodependent diabetes mellitus (IDDM) and compared to that of healthy controls in Tunisian population. An increase of A30, DR3, DR4, Bf F1, C4AQ0 and C4BQ0 and decrease of ...