HLA-DR4 and HLA-DR10 motifs that carry susceptibility to rheumatoid arthritis bind 70-kD heat shock proteins. Nat Med 1996;2:306-10.Auger, I.;Escola, J. M.;Gorvel, J. P., et al. (1996). HLA-DR4 and HLA-DR10 motifs that carry susceptibility to rheumatoid arthritis bind 70-kD ...
综上所述,HLA-DR4与抗CCP抗体、抗Sa抗体是RA关联较强的正关联危险因素,且可能共同参与RA的活动过程,联合检测HLA-DR4、抗CCP抗体、抗Sa抗体可提高对RA的诊断价值。 【相关文献】 [1]CHEMIN K,KLARESKOG L,MALMSTRO·M V. Is rheumatoid arthritis an autoimmune disease?[J]. Curr Opin Rheumatol,2016,28(2...
半胱氨酸与3-羟基丙酸（3-hydroxypropionate，3-HPA）结合形成硫醚键时，产生半胱氨酸羧乙基化修饰，该反应需要胱硫醚β合酶催化。其中整合素96位半胱氨酸（ITGA2B-96Cys）羧乙基化修饰，激活了溶酶体降解途径，产生羧乙基化ITGA2B修饰肽，增强了HLA-DR4复合物中该修饰肽的募集。经TCR克隆验证等多种方法证实，该...
但我国地域辽阔,民族众多,生活习惯差别较大,故深入研究我国不同地区和民族RA患者的HLA-DR4基因分布情况,有助于深入揭示我国RA发病的遗传背景,对进一步明确RA的发病机制以及对RA的早期诊断和防治有重要意义。【参考文献】[1]Stastny P. Association of the B-cell alloantigen DRw4 with rheumatoid arthritis[J]. N...
Rheumatoid ArthritisThe results of a previous study led us to believe that the association of HLA-DR4 and rheumatoid arthritis could be of particular interest in our region. In this work we typed 58 caucasoid patients in the Marseilles area by microlymphocytotoxicity assay in B-cells. HLA-DR4 ...
关键词: 人类白细胞抗原-DR4, 抗环瓜氨酸肽抗体, 抗Sa抗体, 类风湿性关节炎 Abstract: Objective To investigate the determinations of human leucocyte antigen(HLA)-DR4,anti-cyclic citrullinated peptide(CCP) antibody and anti-Sa antibody for the diagnosis of rheumatoid arthritis(RA),and to provide ...
Autoantigen BiP-Derived HLA-DR4 Epitopes Differentially Recognized by Effector and Regulatory T Cells in Rheumatoid Arthritis doi:10.1002/art.39054The balance between effector and regulatory CD4+ T cells plays a key role in the pathogenesis of rheumatoid arthritis (RA). The aim of this study was ...
HLA-DRB1*04基因型患者产生新生抗原特异性自身抗体和T细胞应答,该反应与患者体内3-HPA水平存在相关性。3-HPA给药联合ITGA2B-ceC96抗原肽免疫HLA-DR4转基因小鼠,可诱导小鼠再现肠炎及脊柱病变。 总结来说,半胱氨酸羧乙基化修饰是体内代谢...
HLA—DR4和HLA—DR53与自身抗体检测对 诊断类风湿关节炎的价值 谭立明,张玉红,彭卫华,李华,陈娟娟,詹克勤 南昌大学第二附属医院检验科(南昌330006); 南昌大学第二临床学院(南昌330006); 南昌大学第一附属医 院检验科(南昌330006); 江西省婺源县人民医院检验科(333200) ...
V Taneja NK Mehra AN Chandershekaran RK Ahuja YN Singh AN Malaviya (1992)HLA-DR4-DQw8, but not DR4-DQw7 haplotypes occur in Indian patients with rheumatoid arthritisRheumatol Int116 251–2551:STN:280:By2B2MzpsF0%3D1579806 CASPubMedGoogle Scholar ...