Single-cell transcriptome profiling of sepsis identifies HLA-DRlowS100Ahigh monocytes with immunosuppressive function Ren-Qi Yao, Peng-Yue Zhao, Zhi-Xuan Li, Yu-Yang Liu, Li-Yu Zheng, Yu Duan, Lu Wang, Rong-Li Yang, Hong-Jun Kang, Ji-Wei Hao, Jing-Yan Li, Ning Dong,...
IFN-γ activates JAK-STAT1 and requires IRF family genes, such as IRF1, IRF2, IRF3, and IRF9 to promote gene transcription [18]; alternatively, NLR family CARD domain containing 5 (NLRC5) can form an MHC class I enhanceosome [19], binding to ATF1/CREB and the NFY-complex to activat...
7,Opele G.For the collaborative transplant study:Surval of DNA HLA-DR typed and matched cardaver kidney transplants.Lancet,1991,338:461. 8,Olerup O,Zetterquist H.HLA-DR typing by PCR-amplification with sequence-sspecific primers in 2 hours:an alternative to serological DR typing in clinical...
NOD-like receptor family CARD domain containing 5 (NLRC5) and signal transducer and activator of transcription 1 (STAT1) are important regulators of HLA gene expression as a part of coordinated immune responses to infections. In human embryonic kidney cells, NLRC5 binds and transactivates HLA ...
因而需要一种以抗原为目标的新抗肿瘤抗体,并且可预期由属于II类主要组织相容性复合体(MHC)分子的HLA-DR引发的单克隆抗体作为可识别与Rituximab所识别抗原相异的抗原的抗体,将具有临床抗肿瘤活性。 与此相反,II类主要组织相容性复合体(MHC)分子与抗原肽片段结合,并将这些抗原肽片段呈递至辅助(CD4+)T细胞(“Th”...
HLA-DR and polymorphisms at positions 238 and 308 of TNF-α gene were determined in 137 Mexican RA patients (44 with severe and 93 with non-severe RA) as well as in 169 healthy controls (99 were typed for HLA-DR). We observed an increased frequency of HLA-DR4 in severe RA compared ...
Workflow for candidate gene identification. a Genes were selected as candidate therapeutic targets if tumor-exclusive, frequent HLA-presented peptides were detected and if the source genes were involved in ccRCC-enriched pathways in ccRCC cohort 1. The candidate genes were validated and further filtere...
B. HLA-DM acts as a molecular chaperone and rescues empty HLA-DR molecules at lysosomal pH. Immunity 6, 293–302 (1997). 5. Denzin, L. K., Hammond, C. & Cresswell, P. HLA-DM interactions with intermediates in HLA-DR maturation and a role for HLA-DM in stabilizing empty HLA-DR ...
Integration of genetic and gene expression data thus allowed us to identify the actual disease variants at the LCE3 cluster among the psoriasis patients in India. Psoriasis is a recurrent chronic inflammatory skin disorder, caused by hyper-proliferating keratinocytes that fail to differentiate properly,...
HLA genes, located on the short arm of chromosome 6, encode major histocompatibility complex proteins crucial for immune function. They are categorized into Class I (A, B, C) presenting intracellular antigens and Class II (DR, DQ, DP) presenting extracellular antigens to T cells. These genes...