HLA-DR1 AntigenGene FrequencyAdultHLA-B AntigensAge of OnsetGenetic Predisposition to DiseaseMexicoTo investigate the role of HLA-B and HLA-DR genes as contributors to genetic susceptibility and clinical expression of the spondyloarthropathies (SpA) in the Mexican population. The study included 172...
Single-cell transcriptome profiling of sepsis identifies HLA-DRlowS100Ahigh monocytes with immunosuppressive function Ren-Qi Yao, Peng-Yue Zhao, Zhi-Xuan Li, Yu-Yang Liu, Li-Yu Zheng, Yu Duan, Lu Wang, Rong-Li Yang, Hong-Jun Kang, Ji-Wei Hao, Jing-Yan Li, Ning Dong,...
IFN-γ activates JAK-STAT1 and requires IRF family genes, such as IRF1, IRF2, IRF3, and IRF9 to promote gene transcription [18]; alternatively, NLR family CARD domain containing 5 (NLRC5) can form an MHC class I enhanceosome [19], binding to ATF1/CREB and the NFY-complex to activat...
HLAloci have long been known to be hyper-polymorphic (Thorsby2009). For example, the polymorphicHLA classes IandIIhave approximately 100 times more alleles than the less-polymorphicHLAloci and the presence ofHLA-DRB3,HLA-DRB4, andHLA-DRB5varies across individuals (Robinson et al.2020). These...
HLA-Ⅱ类抗原传统配型有血清学和细胞学两种,需大量标准血清及纯合子分型细胞,耗时大、精确性差(DR抗原血清学配型与基因配型相比错配率达25%[27])。随着聚合酶链式反应(PCR)技术广泛应用及HLA复合体等位基因碱基序列的阐明,基因配型迅速发展,目前已有近十种基因配型方法,常用的有序列特异性寡核苷酸探针配型(PCR-SSO...
因而需要一种以抗原为目标的新抗肿瘤抗体,并且可预期由属于II类主要组织相容性复合体(MHC)分子的HLA-DR引发的单克隆抗体作为可识别与Rituximab所识别抗原相异的抗原的抗体,将具有临床抗肿瘤活性。 与此相反,II类主要组织相容性复合体(MHC)分子与抗原肽片段结合,并将这些抗原肽片段呈递至辅助(CD4+)T细胞(“Th”...
NOD-like receptor family CARD domain containing 5 (NLRC5) and signal transducer and activator of transcription 1 (STAT1) are important regulators of HLA gene expression as a part of coordinated immune responses to infections. In human embryonic kidney cells, NLRC5 binds and transactivates HLA ...
HLA-DR and polymorphisms at positions 238 and 308 of TNF-α gene were determined in 137 Mexican RA patients (44 with severe and 93 with non-severe RA) as well as in 169 healthy controls (99 were typed for HLA-DR). We observed an increased frequency of HLA-DR4 in severe RA compared ...
Workflow for candidate gene identification. a Genes were selected as candidate therapeutic targets if tumor-exclusive, frequent HLA-presented peptides were detected and if the source genes were involved in ccRCC-enriched pathways in ccRCC cohort 1. The candidate genes were validated and further filtere...
ORIGINAL ARTICLE Journal of Human Genetics (2011) 56, 423–427 & 2011 The Japan Society of Human Genetics All rights reserved 1434-5161/11 $32.00 www.nature.com/jhg HLA-C, CSTA and DS12346 susceptibility alleles confer over 100-fold increased risk of developing psoriasis: evidence of gene ...