Regulation of HLA-DR Gene Expression in Cultured Human Thyroid Cells: A Role for Lectin, Gamma Interferon, and CyclosporineHLA Class II antigens (DR, DQ, and DP) are expressed primarily on the surface of the lymphocytes (B and activated T cells) and cells of the monocyte-macrophage lineage...
The genetics of HLA-DR is complex. HLA-DR is encoded by several loci and several 'genes' of different function at each locus. The DR α-chain is encoded by the HLA-DRA locus. Unlike the other DR loci functional variation in mature DRA gene products is absent. (Note: see t...
研究中入组对象均为T-SPOT检测阳性,结合临床和实验室评估,入组对象被划分为ATB患者以及LTBI患者两个队列。ATB的诊断标准为“分枝杆菌培养阳性和/或GeneXpert MTB/RIF结果阳性,且包含ATB相关支持性症状和放射学表现”;LTBI的诊断标准为“...
HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 enc...
HLA-DR Gene and Hepatitis 梁红霞 (郑州大学第一附属医院感染病科 河南郑州 450052) HLA 与疾病关联研究始于 1967 年,至今研究过的 疾病超过 500 种,但有关 HLA 与肝炎的研究却是从近 些年开始的。 HLA(human leucocyte antigen)基因系统是人类主要 ...
DRB3,HLA-DRB4,HLA-DRB5and20allelesofHLA-DRB1genesitesof101peoplewhocomefromGuangdong,Guangxi, Hunan,Hubei,JiangxiandFujian.ResultsThefirst,therewashigherhaplotypefrequencybetweenDR13.3and DRB3,DRB4andDRB5thanotherswhileDR103andDR14.3didnotalmostlinkwithDRB3,DRB4andDRB5.Thesecond, ...
Entrez Gene:3122 Swiss Prot:P01903 Source:KLH conjugated synthetic peptide derived from human HLA-DRA:1-100/254 Purification:affinity purified by Protein A Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid re...
The alpha chain gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain ...
Identification of a polymorphic variant associated with HLA-DQw3 and characterized by specific restriction sites within the DQ beta-chain gene Restriction endonuclease digestion of genomic DNA from 24 lymphoblastoid cell lines homozygous for the HLA class II specificity DQw3, followed by hybridiza... ...
A relevance between human solid tumor and HLA-DR gene polymorphismHLA抗原肿瘤基因目的 通过检测部分肿瘤患者HLA-Ⅱ类基因座位的13个等位基因位点,探讨人体部分实体肿瘤与HLA-DR基因多态性的关联性.方法 采用聚合酶链反应-序列特异性引物(PCR-SSP)技术,检测17例部分肿瘤患者的HLA-DR基因位点13个,并以144...