David Z. Drew MDJan Melenhorst Ph.D *Nancy F. Hensel Ph.D *A. John Barrett MD, FRCP
Moreover, we found that S100A9+ monocytes exhibited profound immunosuppressive function on CD4+ T cell immune response and blockade of S100A9 using Paquinimod could partially reverse sepsis-induced immunosuppression. Conclusions This study identifies HLA-DRlowS100Ahigh monocytes correlated with ...
K Nishimaki T Kawamura H Inada K Yagawa Y Nose N Nabeya G Isshiki N Tatsumi S Niihira (2000)HLA DPB1*0201 gene confers disease susceptibility in Japanese with childhood onset T1D, independent of HLA-DR and DQ genotypesDiabetes Res Clin Pract471 49–551:CAS:528:DyaK1MXnslyhu7w%3D1066022...
HLA-DR−/lowCD33+CD16−myeloid cells expanded in PB and PBSC after G-CSF administration and exerted a strong immunosuppressive effect on T cell proliferation.a,bThe frequency and cell number of different kind of MDSCs and HLA-DR−/lowCD33+CD16−population in ten donors (H-PB, G-PB...
Myeloid recovery was defined as maintenance of an absolute neutrophil count above 0.5 × 109·L−1 for 3 consecutive days after the neutrophil nadir. Chimerism was determined by at least 2 of the following 3 methods: DNA-based HLA typing (for mismatched loci), polymerase chain reaction (PCR...
Recognition of a peptide/HLA (pHLA) ligand by a CD8+T cell is determined by the sequence and functional characteristics of its T cell receptor (TCR)21,22. The exceptional diversity of the TCR repertoire, generated by somatic recombination of variable (V), diversity (D), and joining (J) ...
到ＨＬＡ相合的亲缘供者。随着ＨＬＡ配型技术研究的进步和大型国际供者登记处的建立，非亲缘异基因骨髓移植（ＵＲＤ．ＢＭＴ）开展日益增多。成为造血干细胞移植重要的干细胞来源之一。非亲缘异基因骨髓移植和亲缘异基因骨髓移植相比，其并发症多，移植相关死亡率高，尤其是严重的移植物抗宿主病（ＧＶＨＤ）和植入...
HLA-DR alleles display sex-dependent effects on survival and discriminate between individual and familial longevity.Hum. Mol. Genet.(2), 187–194. Morrison, B. A.Multiple sclerosis risk markers in HLA-DRA, HLA-C, and IFNG genes are associated with sex-specific childhood leukemia risk.(8), ...
NES indicates the absolute GSEA normalized enrichment score. (G) Enrichment scores for the core genes in signatures enriched in B∗46− NK cells.See also Figures S5 and S6. A specific NK cell population, but not the phenotype associating with B∗46, is present prior to HIV infection ...
loss of a previous graft due to immunological reasons in the first year after transplantation, receipt of an organ donated after cardiac death, donor age <5 or >65 years, current or peak panel reactive antibodies (PRA) >25%, platelets <75,000/mm3, an absolute neutrophil count of <1.500/...