结果(1)普通型、重型和危重型HFMD患儿单核细胞HLA-DR阳性表达存在显著性差异( F=47.102, P<0.05),危重型HLA-DR表达水平降低更显著( P<0.05);(2)DR抑制组外周血CD14 +单核细胞、CD3 +T细胞、CD4 +T细胞、CD8 +T细胞、B细胞、NK细胞数量均明显低于DR正常组和对照组,重型和危重型HFMD免疫细胞数量减少更明显(...
There are very few cohorts with longitudinal measurements of HIV VL and CD4+ T cell counts (CD4 counts) among ART-naive individuals since the successful implementation of a universal test-and-treat (UTT) strategy, where ART is started following HIV diagnosis regardless of CD4 count and WHO ...
IL-7/IL-7R interaction is important for maintenance of memory T cells, development, survival and proliferation of T and B cells [78]. Furthermore, IL-17R plays a significant role in controlling homeostasis of CD4+T cells [77]. IL17R gene, at the 5p13 region, has several polymorphisms. ...
Expression of certain class I human leukocyte antigen (HLA) alleles, particularly at the HLA-B locus8,9, is associated with lower plasma viral loads, higher CD4+ T cell counts and delayed onset of AIDS10,11. Interaction between CD8+ T cells and viral peptide epitopes presented on HLA ...
In addition, eligible patients had to have an Eastern Cooperative Oncology Group performance status (ECOG-PS) of 0–1, adequate organ/marrow function (absolute neutrophil count ≥1.0 × 109 per liter without granulocyte colony-stimulating factor support, platelets ≥75,000 per microliter, ...
S Easteal M Viswanathan SW Serjeantson (1990)HLA-DP,-DQ and -DR RFLP types in south Indian insulin dependent diabetes mellitus patientsTissue Antigens352 71–741:STN:280:By%2BB28%2Fos1Q%3D1971463 CASPubMedGoogle Scholar K Nishimaki T Kawamura H Inada K Yagawa Y Nose N Nabeya G Isshiki...
Moreover, we found that S100A9+ monocytes exhibited profound immunosuppressive function on CD4+ T cell immune response and blockade of S100A9 using Paquinimod could partially reverse sepsis-induced immunosuppression. Conclusions This study identifies HLA-DRlowS100Ahigh monocytes correlated with ...
The human leukocyte antigen (HLA) haplotype DRB1*15:01 is the major risk factor for multiple sclerosis (MS). Here, we find that DRB1*15:01 is hypomethylated and predominantly expressed in monocytes among carriers of DRB1*15:01. A differentially methylate
At 3 months after HSCT, the peripheral blood counts of CD4+ T cells were 129.00 (24.88-510.82·μL−1. The median of CD8+ cell counts at +60 days was 526.50 (4.54-2742.73)·μL−1 and returned to normal (median: 656.3·μL−1; range: 50.92·μL−1-3708.04·μL−1) ...
Significant anti-tumor immune responses mediated by hTERT TAA have been observed in patients, but an enhanced CD4+ helper T (Th) cell response is required for the induction and maintenance of anti-tumor immune responses [68–70]. Like CD8+ CTLs, CD4+ Th cells do not become activated until...