Comparison of asparagine-linked oligosaccharides from HLA class I and HLA class II molecules was done on normal and transformed cells excluding the influence of genetic polymorphism. B cells and monocytes were isolated from peripheral blood of a volunteer donor and an EBV transformed B lymphoblastoid ...
(DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26...
Recent studies have shown that although HLA-II molecules are considered to be less broadly expressed than HLA-I on nonimmune cells, there is significant expression of HLA-II on tumor cells22. Several studies have also linked HLA-II expression on tumors with increased antitumor immunity mediated b...
both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and ...
背景资料:HLA-DMBbelongstotheHLAclassIIbetachainparalogues.ThisclassIImoleculeisaheterodimerconsistingofanalpha(DMA)andabeta(DMB)chain,bothanchoredinthemembrane.Itislocatedinintracellularvesicles.DMplaysacentralroleinthepeptideloadingofMHCclassIImoleculesbyhelpingtoreleasetheCLIP(classII-associatedinvariantchainpeptide...
For the field of basic immunology our findings could be provocatively interpreted to suggest that B cells, through their B cell receptor (BCR), are able to recognize peptides bound to MHC class II molecules and through this recognition generate antibodies directed at a specific MHC peptide ...
(1996) HLA-DM functions as a chaperone-like protein in the assembly of MHC class II molecules. Science 274(5285): 618–620. 2.Ruppert J, et al. (1993) MHC class II-peptide interaction: A flexible two-step model. Biochemistry 32(40): 10475–10485. 3.Rudolph MG, et al. (2006) ...
MHC class II molecules are transmembrane glycoproteins composed of an alpha chain (36 kDa) and a beta chain (27 kDa). They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. Three loci, DR, ...
相关药物基因组学研究已发现人类白细胞抗原(HLA)基因与药物性肝损伤之间有很强的遗传相关性。综述了药物性肝损伤的HLA基因多态性研究进展,以期揭示免疫因素在药物性肝损伤发生机制中的作用,发现相应基因生物标志物,提高临床用药的安全性。 ...
These results highlight a high degree of repertoire overlap amongst all HLA class II molecules, perhaps reflecting binding in multiple registers, and more pronounced dependence on backbone interactions rather than peptide anchor residues. This fundamental difference between HLA class I and class II ...