HLA class I polymorphism: structure and function and still questions. Hum. Immunol. 57:1.Kostyu, D.D., L.I. Hannick, J.L. Traweek, M. Ghanayem, D. Heilpern, and D.V. Dawson. 1997. HLA class I polymorphism: structure and function and still questions. Hum Immunol. 57:1-18....
Class I major histocompatibility complex (MHC) molecules bind, and present to T cells, short peptides derived from intracellular processing of proteins. The peptide repertoire of a specific molecule is to a large extent determined by the molecular structure accommodating so-called main anchor positions...
*可分为下列功能区(1)肽结合区:结合抗原肽,多态性区域(1+1)(2)Ig样区:与CD4分子结合的部位(3)跨膜区和胞浆区HLAII类分子呈递外源性抗原肽给CD4+T细胞HLA-II类分子的结构ThestructureofanMHCclassIImolecules(resembleMHCclassImoleculesinstructure)人人文库> 全部分类> 教育资料 > 课设设计 ...
The class I histocompatibility antigen from human cell membranes has two structural motifs: the membrane-proximal end of the glycoprotein contains two domains with immunoglobulin-folds that are paired in a novel manner, and the region distal from the mem
A. et al. A naturally selected dimorphism within the HLA-B44 supertype alters class I structure, peptide repertoire and T cell recognition. J. Exp. Med. 198, 679–691 (2003). Article Google Scholar Jurtz, V. et al. NetMHCpan-4.0: improved peptide-MHC class I interaction predictions ...
At present, we have no structural explanation for this finding, and probably the determination of the three-dimensional structure of B40 will be required in order for light to be shed on this issue. As in other HLA class I antigens, the second most influential position for binding to B*40...
The human leukocyte antigen (HLA) class I system comprises a highly polymorphic set of molecules that specifically bind and present peptides to cytotoxic T cells. HLA-B*1501 is a prototypical member of the HLA-B62 supertype and only two peptide-HLA-B*1501 structures have been determined. Her...
Recombinant Human HLA class I histocompatibility antigen, alpha chain G (HLA-G) structure CAS No. Chemical Name: Recombinant Human HLA class I histocompatibility antigen, alpha chain G (HLA-G) Synonyms Recombinant Human HLA class I histocompatibility antigen, alpha chain G (HLA-G);Recombinant ...
HLA-A Major histocompatibility complex, class I, A HLA-A2 with bound peptide Available structures: 1akj, 1ao7, 1b0g, 1b0r, 1bd2, 1duy, 1duz, 1eey, 1eez, 1hhg,
The structure of the human major histocompatability (MHC) class I molecule HLA-A*0301 (HLA-A3) in complex with a nonameric peptide (KLIETYFSK) has been determined by X-ray crystallography to 2.7 Å resolution. HLA-A3 is a predisposing allele for multiple sclerosis (MS), an autoimmune...