HLA-B27immunologyrheumaticdiseaseuveitisAcute anterior uveitis is a common ocular disease characterized by inflammation of the iris and ciliary body. In the majority of patients presenting with an acute attack of anterior uveitis, the only clues to the pathogenesis of this disease are its close ...
Rothova等人也发现,10%的低视力和法定盲由 HLA-B27抗原相关性前葡萄膜炎引起。因此,HLA-B27阳性前葡萄膜炎日益受到临床眼科医生关注。 【参考文献】 [1] 我国急性前葡萄膜炎临床诊疗专家共识(2016年) [2] Tsirouki T,Dastiridou A,Symeo...
过去认为,HLA-B27分子与多肽(多为第2位为精氨酸的9肽)结合形成的复合物被CD8+细胞毒T淋巴细胞识别后触发的自身免疫反应是HLA-B27唯一的致病机制。但国外May等[9]发现,只表达转染的人HLA-B27重链,剔除了β2微球蛋白基因的HLA-B27转基因鼠仍可...
HLA-B27geneticsβ2MAcute anterior uveitis (AAU) is by far the most common form of uveitis [6]. It is characterized by a breakdown in the blood–aqueous barrier and acute inflammation of the iris and ciliary body. Immunopathologically, there is up-regulation of cell adhesion molecules on the...
[1] Suhlerad EB, Matin TM, Rosenbaum JT. HLA-B27-associated uveitis: overview and current perspectives[J]. Curr Opin Ophthalmol, 2003, 14: 378-383. [2] Pato E, Banares A, Jover JA, et al. Undiagnosed spondyloarthropathy in patients presenting with anterior uveitis[J]. J Rheum, 2000,...
However, the majority of the HLA-B27 ... PJFM Derhaag,TEW Feltkamp - 《International Ophthalmology》 被引量: 441发表: 1990年 Outcomes of HLA-B27-positive and HLA-B27-negative acute anterior uveitis. PURPOSE: Outcomes of HLA-B27-positive and HLA-B27-negative acute anterior uveitis were ...
Kerkhoff F T, Rothova A.Bartonella henselae associated uveitis and HLA -B27 [J] .BrJOphthalmol, 2000, 84 (10): 1125.Kerkhoff FT, Rothova A. Bartonella henselae associated uveitis and HLA-B27. Br J Ophthalmol 2000; 84:1125-9.Kerkhoff FT, Rothova A, Bartonella henselae associated ...
Torres S, Borges S, Artiles A. HLA-B27 and clinical features of acute anterior uveitis in Cuba. Ocul Immunol Inflamm 2013;21:119-123.Torres S, Borges S, Artiles A (2013) HLA-B27 and clinical features of acute anterior uveitis in Cuba. Ocul Immunol Inflamm 21: 119-123....
HLA B27, sacro-iliitis and peripheral arthropathy in acute anterior uveitis. Scand J Rheumatol 1980;9:234-6.Moller, P., Vinje, O., Gronvold Olsen, E. HLA-B27, sacro-iliitis and peripheral arthropathy in acute anterior uveitis. Scand J Rheumatol 1980, 9, 234–236....
HLA-A and B antigens were determined in 37 unrelated patients with acute non-granulomatous anterior uveitis (AAU) and in 114 control subjects. HLA-B27 was identified in 31 patients with AAU (83.8%) and in 15 control subjects (13.2%). Fifteen patients (40.5%) had associated rheumatic disease...