HLA-B27 positivity makes the onset of autoimmune diseases such as uveitis, ankylosing spondylitis and Crohn's disease more likely to occur. Ankylosing spondylitis and Crohn's disease are two types of HLA-B27 positive diseases that demonstrate a direct association with uveitis. Although the possession...
HLA-B27 is a serologically identified group of human class I MHC molecules that is very closely associated with the human diseases ankylosing spondylitis, reactive arthritis, and acute anterior uveitis. A number of infectious agents are known to trigger reactive arthritis in HLA-B27-positive ...
聚合酶链式反应SSP 法和酶联免疫吸附试验检测强直性脊柱炎患者HLA-B27的比较[J]. 工企医刊,2014,27(3):800-801.PENG Ping, ZHANG Hao, XIE Lihua. Comparison of polymerase chain reaction SSP method and enzymelinked immunosorbent assay for detecting HLA-B27 in patients with ankylosing spondylitis [J]...
Positive- The positive results indicate a high risk of autoimmune disease. The presence of HLA-B27 increases the risk of developing autoimmune and inflammatory diseases like- Ankylosing spondylitis, Reactive arthritis, Juvenile idiopathic arthritis, Anterior uveitis, Behçet's disease, and Psoriatic arth...
Human leucocyte antigen B*27 (HLA-B*27) is strongly associated with inflammatory diseases of the spine and pelvis (for example, ankylosing spondylitis (AS)) and the eye (that is, acute anterior uveitis (AAU))1. How HLA-B*27 facilitates disease remains unknown, but one possible mechanism co...
DrugsandADRs(药物与急性皮肤反应)Drug(药物)Carbamazepine痛痉宁(镇痛,抗惊厥药)Treatment(治疗)Epilepticseizures,neuralgiaandotherneuraldiseases癫间,神经痛,神经疾病ADR HLAAlleleassociatedtoADR SJS/TEN*HLA-B*1502 Allopurinol别嘌呤醇(治痛风)Gout(痛风病)SJS/TEN*HLA-B*5801 SJS:Steven-Johnson综合症TEN:...
(HLA).MorbidityofASiScloselyrelatedwithHLA—B27positive,andconcernedwithseveralallelessuchasB7,B13andB40. Therea陀42allelesinHLA—B,inwhichHLA—B27hashighlypolymorphism,containsmorethan22subtypes。andthebasese- quenceofthesesubtypeshasfewindividualdiferences.ThedistributionofthesubtypesofHLA—B27inASpatientshave...
HLA-B27: The Facts HLA-B27 (an abbreviation for "Human Leukocyte Antigen B27") or HLA-B*27 (according to the most recent nomenclature) is one of the HLA class I surface molecules encoded in the B locus of the major histocompatibility complex (MHC) on the short arm of chromosome 6 (...
CD8-Positive T-LymphocytesT-Lymphocytes, CytotoxicL Cells (Cell LineBacterial ProteinsObjective. The association of reactive arthritis (ReA) with HLA-B27 and the presence of bacterial antigen in joints with ReA suggest that bacterial peptides might be presented by the HLA-B27 molecule and thus ...
Activation of complement with zymosan induced higher mean levels of the anaphylatoxin C3a in HLA-B27 positive sera (mean (SD) 7.40 (1.66) mg/l) than in HLA-B27 negative sera (6.41 (1.79) mg/l). Similarly, higher levels of C3d,g, another C3 breakdown fragment, were obtained in HLA-...