HLA and autoimmune diseases: Type 1 diabetes (T1D) as an example. Autoimmun Rev 2006; 5: 187-194.Gorodezky C, Alaez C, Murguia A et al (2006) HLA and autoimmune diseases: Type 1 diabetes (T1D) as an example. Autoimmun Rev 5:187–194...
HLA associations with autoimmune Addison's disease The finding that diseases such as type I diabetes, coeliac disease and multiple sclerosis are HLA-DQ associated is not easily explained by a simple hypothesis of DQ-restricted, autoreactive T cells, considering the generally marginal rol... A.,P...
Associations between particular human leukocyte antigen (HLA) alleles and susceptibility to—or protection from—autoimmune diseases have been long observed. Allele-specific antigen presentation (AP) has been widely proposed as a culprit, but it is unclear whether HLA molecules might also have non-AP,...
The association between genetics, particularly the genes of the Major Histocompatibility Complex (MHC) and manyautoimmune diseaseshas long been known even though the actual disease susceptibility genes or the mechanism that confers the disease often remain to be elucidated. Here we discuss a number of...
Autoimmune diseases—connecting risk alleles with molecular traits of the immune system. Nat. Rev. Genet. 17, 160–174 (2016). Article PubMed PubMed Central Google Scholar Raj, T. et al. Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes. Science 344, ...
However, overexpression of HLA-G is induced under multiple pathological conditions, including malignant tumors, viral or microbial infections [8,9,10,11], and autoimmune diseases [12, 13] Convergent data implicated that HLA-G was enriched in several tumors, thereby fueling the immune evasion. ...
perspectives biology of the human histocompatibility leukocyte antigen (hla) system and a hypothesis regarding the generation of autoimmune diseases JL Strominger 被引量: 0发表: 2018年 [The HLA (human leukocyte antigen) system] KEYWORDS Immunogenetics; HLA; MHC; molecular biology ABSTRACT The ...
HLA Class II Gene Polymorphism: DNA Typing, Evolution, and Relationship to Disease Susceptibility The detection of HLA class II polymorphism is valuable in the areas of individual identification, tissue typing for transplantation, and genetic susceptibility to specific autoimmune diseases. Polymorphism in ...
HLA 美[h'lə] 英[h'lə] n.人体白细胞抗原;组织相容性抗原 网络人类白细胞抗原(human leukocyte antigen);人类白血球抗原;人白细胞抗原 英汉 英英 网络释义 n. 1. 人体白细胞抗原 2. 组织相容性抗原
Indeed, the HLA-DRB1 is the most polymorphic gene within the HLA-II region, and it has been frequently associated with autoimmune diseases such as rheumatoid arthritis (RA), spondylarthritis, systemic lupus erythematosus and multiple sclerosis, among others.32 Moreover, a meta-analysis performed ...