The combination of anti-CCP2 antibodies and the testing of these two HLA-haplotypes proved to be the best approach for detecting RA susceptibility [141]. Other authors found no benefit of additional shared epitope testing owing to its strong association with ACPA [142]. Genotyping of shared ...
Patients and methods: Sera from 147 consecutive patients (75 males and 72 females) with chronic HCV infection at the Mansoura University Hospitals, Egypt during 2008 to 2009, were analyzed for antithyroid antibodies (group 1). A total of 126 anti-HCV positive patients with...
HLA and disease Abstract Association of HLA and diseases is well known. Several population studies are available suggesting evidence of association of HLAs in more than 40 diseases. HLA found across various populations vary widely. Some of the reasons attributed for such variation are occurrence of ...
An inverse disease association exists withHLA-DRB1alleles that encode a protective epitope (PE) motif 70-DERAA-74 (at the exact same region of the DRβ chain as the SE). Those alleles significantly reduce the risk for RA28,29,30,31, and many other autoimmune conditions, including systemic ...
Familial disease, the HLA-DRB1 shared epitope and anti-CCP antibodies influence time at appearance of substantial joint damage in rheumatoid arthritis. Rheumatoid arthritis (RA) progresses more rapidly in some patients than in others and diverse factors influence radiographic progression in a specific po...
Circulating antimicrosoma1 antibodies (Msab) (titre ≥ 400) were present in 73% and antithyroglobulin antibodies Ttitre ≥ 400) in 38%. Of the 17 patients with absent or low tit-re Msab 16 were euthyroid (P < 0.001) and 13 of them were DR4 positive ( P < 0 .05).Conclusion: JAIT...
Characterization of Antibodies Directed against the Immunoglobulin Light κ Chain Variable Chain Region (VK) of Hepatitis C Virus㏑elated Type㊣I Mixed Cry... Autoimmune type㊣I cryoglobulinemia (II㎝C) is sustained by hepatitis C virus (HCV) infection and Bヽell (oligo)clones. This is the rea...
Indeed, citrullinated proteins are increased in patients with COPD and correlate with ongoing inflammation.40 Furthermore, it has been shown that anti-cyclic citrullinated peptide antibodies levels are higher in COPD patients exposed to biomass smoke.41 Although ACPA determination was not performed in ...
sinceHLA antigensmay be expressed on erythrocytes. In one study the erythrocytes of 50% of blood donors contained HLA-A, HLA-B, and HLA-C antibodies (but not antibodies to class II antigens or to leukocyte-specific antigens) [112]. Neither storage at 4°C for 21 days norcryopreservation...
Thyroid autoimmunity was assessed by antithyroglobulin and antithyroid peroxidase antibodies and with diagnostic ultrasonographic findings. RESULTS: ATD was detected in 31.5%, and CD-in 7.8% of T1D patients. Subjects with CD showed either no symptoms or suggestive problems such as short stature, ...