首先,桑那非素(Carbamazepine)是针对HLA-B*1502阳性受检者推荐给药前进行HLA-B*1502基因筛查的药品。由于桑那非的过敏反应与HLA-B*1502阳性受检者有特殊的适应性,因此建议给药前必须对桑那菲的受检者进行HLA-B*1502基因筛查。 其次,当受检者拥有HLA-B*1502阳性状态时,会有大量受检者在接受治疗桑那菲时出现严重的...
HLA-B*1502基因检测可用于确定患者是否高度敏感少数疾病,如抗原性酮风。在进行抗细胞抗原反应时,一定要正确检测患者的HLA-B*1502基因,并按照相应的推荐方案选择给药。 推荐在给药前进行HLA-B*1502基因筛查的药物包括carbamazepine和phenytoin,它们往往被用于治疗癫痫和抑郁症。这些药物可引起药物性表皮反应,特别是当患者...
HLA-B*1502 strongly predicts carbamazepine- induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Thai patients with neuropathic pain. Pain Pract. 12 (3), 202-208.Kulkantrakorn K, Tassaneeyakul W, Tiamkao S, et al. HLA-B*1502 strongly predicts carbamazepine-induced Stevens-Johnson ...
Screening for the HLA-B*1502 allele before prescribing carbamazepine is less costly than the treatment of carbamazepine-induced Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) in Thailand. This is the main finding of a study that compared the cost of HLA-B*1502 screening to ...
HLA-B*1502位点检测定制服务(卡马西平) 美国警告含HLA-B*1502基因患者服用卡马西平更易发生严重皮肤反应 2008年02月22日 美国食品药品监督管理局(FDA)发布关于卡马西平的安全性信息,信息称,卡马西平(carbamazepine)会引起危险的甚至致命的皮肤反应(史蒂文斯-约翰逊综合征和中毒性表皮坏死溶解症),尤其在含人白细胞抗原等...
本文报告1例患者服用卡马西平导致重症多形红斑药疹,通过基因检测明确患者为HLA-B*1502等位基因阳性,结合患者基因型及临床因素,分析该患者发生重症药疹的原因,以引起临床关注。 临床资料 1 病例简介: 患者,男,35岁,于2016-08-01以“肺癌...
HLA-B*1502Previous studies have demonstrated a strong association between carbamazepine (CBZ)-induced Stevens-Johnson syndrome (SJS) and HLA-B*1502 in Han Chinese. Here, we extended the study of HLA-B*1502 susceptibility to two different antiepileptic drugs, oxcarbazepine (OXC) and phenobabital ...
in Chinese Han population,but not in Caucasian.Ethinicity might be a risk factor.Carbamazepine is prescribed in clinical work currently,the objective of this study is to review accociation HLA-B*1502 with carbamazepine-indeced SJS/TEN in Chinese Han population and provide reference for drug ...
摘要: Purpose The purpose of this study is to examine the association of HLA-B*1502 allele with CBZ-induced SJS/TEN in the mainland Han Chinese population.关键词: HLA-B*1502 – Carbamazepine – Stevens-Johnson syndrome – Toxic epidermal necrolysis – Mainland Chinese ...
中国大陆汉族人卡马西平过敏性药疹与HLA—B1502的关联性分析829 卡马西平(carbamazepine,CBZ)不但是临床常用的一线抗癫痫药物.还可用于治疗各种神经痛,双相情感障碍等,是神经精神领域广泛应用的药物.但部分患者服用后易发生过敏性药疹,临床表现从轻型的斑丘疹(maculopapulareruption, MPE).到可以危及生命的重型药疹.后者...