To estimate the fitness function under NFV selective pressure, clinical data was pooled from the Stanford HIV Drug Resistance Database (Kantor et al., 2001), from the University Hospitals, Leuven, Belgium, and from Hospital Egas Monis, Lisbon, Portugal, to create a treated population PT of 1...
Additionally, the studies utilized genotyping methods for evaluating HIVDR and employed the Stanford HIV Drug Resistance Database (http://hivdb.stanford.edu) for resistance assessment. Exclusion criteria comprised studies using data from gene banks or relying on information from medical records of ...
Protease substitutions were classified as major or minor according to IAS-USA (2007) and the HIV Drug Resistance Database (HIVdb). Protease polymorphisms were defined as either: 1) IAS-USA minor substitutions assigned a score of 0 by the Stanford HIV database (HIVdb Genotype Resistance ...
1999). Sequences are analyzed by one of several drug resistance interpretation algorithms such as the rule-based algorithm developed by the Stanford HIV Drug Resistance Database (Liu and Shafer, 2006), in which the sequences are examined for the presence of known or suspected resistance mutations...
Rationale and Uses of a Public HIV Drug‐Resistance Database Knowledge regarding the drug resistance of human immunodeficiency virus (HIV) is critical for surveillance of drug resistance, development of antiretrovira... Robert W. Shafer - 《Journal of Infectious Diseases》 被引量: 350发表: 2006年...
Mbisa JL, Fearnhill E, Dunn DT, Pillay D, Asboe D, Cane PA; UK HIV Drug Resistance Database. Evidence of self-sustaining drug resistant HIV-1 lineages among untreated patients in the United Kingdom. Clin Infect Dis. 2015;61(5):829-836.PubMedGoogle ScholarCrossref 21. Vernazza P, ...
DRM analyses in PR-RT and IN regions were performed in the Stanford HIV Drug Resistance Database (https://hivdb.stanford.edu)59 using Stanford HIVdb Program Genotypic Resistance Interpretation Algorithm (https://hivdb.stanford.edu/hivdb/by-sequences)60. Inferred levels of resistance of HIV-1...
Primary resistance to InSTIs was predicted with Stanford University HIV Drug Resistance Database, Genotypic Resistance Interpretation Algorithm version 8.831. HIV-1 subtypes were determined by several algorithms: Rega HIV-1 Subtyping Tool, version 3.0., jumping profile Hidden Markov Model (jpHMM), ...
(***) represent increased susceptibility to the drug if the mutation is present. Refer to table I for a full list of drug name abbreviations and definitions. Adapted from the Stanford University HIV Drug Resistance Database.[40]Cons= consensus wild-type;Ins= insertion;MDR= multi-drug ...
Genotyping analysis was performed using the Stanford University HIV Drug Resistance Database (HIV-DB). One patient experienced progressively lower viral rebounds (269000-31300 at the first and third rebounds, respectively), while the other patient did not experience such a reduction, and the VL of...