In most patients, initiating treatment at that point provides maximal therapeutic effectiveness, in that it minimizes the severity of drug toxicities and thus the risk for discontinuance of treatment and development of drug resistance. However, studies have indicated that in patients with morbidity-...
Monitoring of HIV drug resistance early warning indicators in UgandaNamuwenge Dr, NorahKirungi, WilfordMadraa, ElizabethLule, FrankCrahay, BeatriceKaleebu, Pontiano
Additionally, the studies utilized genotyping methods for evaluating HIVDR and employed the Stanford HIV Drug Resistance Database (http://hivdb.stanford.edu) for resistance assessment. Exclusion criteria comprised studies using data from gene banks or relying on information from medical records of ...
Curbing the rise of HIV drug resistance in low-income and middle-income countries: the role of dolutegravir-containing regimens. Lancet Infect Dis. 2019;19(7):e246–52. Article PubMed PubMed Central Google Scholar Page KR, Doocy S, Reyna Ganteaume F, Castro JS, Spiegel P, Beyrer C. ...
Sites are located in Uganda and Zambia, but recruitment isn’t underway as yet. The first example this type of trial, sponsored by the HIV Vaccine Trials Network (HVTN), was added to our listing in September 2023 and is currently ongoing at multiple sites in the US (this protocol does ...
viral load threshold for virological failure and genotyping, co-administered antiretrovirals, duration of treatment, viral load and CD4 cell count before the start of first-line ART (baseline) and at time of viral failure, and resistance mutations based on the Stanford HIV Drug Resistance Database...
Further investigations found no evidence of drug-resistant TB, with samples of urine and sputum negative for Mycobacterium tuberculosis resistance to rifampicin (MTB-RIF). Urine Mycobacterium tuberculosis cell wall antigen lipoarabinomannan (TB-LAM) on admission was negative. Due to severe nausea and ...
Acknowledgments We would like to thank all of the study participants and study staff at St Mary's Hospital, London, UK, and at the AIDS Information Center, Kampala, Uganda. The authors would also like to thank the SCHARP database management team, the CHAVI manageme...
This is a concern given poor adherence severely compromises effectiveness and is linked with the likelihood of the drug resistance. Non-adherence to ART in this study was associated with socio-demographic characteristics, illicit drug use, and history of taking ART. In the final model in our ...
As of October 30, 2023, the Los Alamos HIV database has documented a total of 140 CRFs for HIV-1. In China, CRF01_AE, CRF07_BC, and CRF08_BC represent the predominant CRFs [6]. Most of the newly reported HIV patients (69.2%) on Hainan Island were needle-sharing drug users, wi...