Sankaran SM, Wilkinson AW, Elias JE, Gozani O (2016) A PWWP domain of histone-lysine N-methyltransferase NSD2 binds to dimethylated Lys-36 of histone H3 and regulates NSD2 function at chromatin. J Biol Chem 291:8465-8474Sankaran, S. M., Wilkinson, A. W., Elias, J. E., and ...
A PWWP Domain of Histone-LysineN-Methyltransferase NSD2 Binds to Dimethylated Lys-36 of Histone H3 and Regulates NSD2 Function at Chromatin The readout of histone modifications plays a critical role in chromatin-regulated processes. Dimethylation at Lys-36 on histone H3 (H3K36me2) is associated...
F, linear correlation is observed between the WT NSD2 enzyme concentration and methyltransferase activity (mean ± S.D.; n = 8). NSD2 has been implicated as a therapeutic target for a variety of cancers. Because the gene is located within the Wolf-Hirschhorn syndrome critical region of ...
Background: The nuclear receptor binding SET domain (NSD) protein is a family of three histone-lysine N-methyltransferase (HMTase), NSD1, NSD2/MMSET/WHSC1, and NSD3/WHSC1L1 that are critical in maintaining the chromatin integrity. NSD1 m... ED Luccio,M Morishita - 《Cancer Research》 被...
SETD8, a methyltransferase that catalyzes the mono-methylation of histone H4 lysine 20 is known to promote tumorigenesis in various cancers and its high levels of expression are related to poor prognosis. However, the detailed mechanisms by which SETD8 stimulates tumor progression and angiogenesis ...
In mammals, the methyltransferases responsible for H3K36 methylation include nuclear receptor binding SET domain protein 1 (NSD1)/KMT3B, NSD2/KMT3G, NSD3/KMT3F, ASH1-like histone lysine methyltransferase (ASH1L)/KMT2H, SMYD2/KMT3C, SET domain-containing protein 2 (SETD2)/KMT3A, SETD3 and...
The EZH2 (enhancer-of-zest homolog 2) subunit (also known as KMT6A) within PRC2 (polycomb repressive complex 2) complex, an evolutionarily conserved class of polycomb group proteins, is an H3K27 methyltransferase153 responsible for all three states of H3K27 methylation.154–156 The mammalian ...
Background: The nuclear receptor binding SET domain (NSD) protein is a family of three histone-lysine N-methyltransferase (HMTase), NSD1, NSD2/MMSET/WHSC1, and NSD3/WHSC1L1 that are critical in maintaining the chromatin integrity. NSD1 m... ED Luccio,M Morishita - 《Cancer Research》 被...
This is due to a domain containing ankyrin repeating at the noncatalytic N-terminal region in G9a, responsible for G9a’s nuclear import, and protein–protein interactions. The hydrophobic cages of the ankyrin repeat domain bind H3K9me1/2 and are not required for histone methyltransfer...
et al. NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming. Mol. Cell 44, 609–620 (2011). CAS PubMed PubMed Central Google Scholar Nimura, K. et al. A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf–Hirschhorn syndrome. Nature 460, 287–291...