SET and MYND domain-containing protein 3 (SMYD3), a histone lysine methyltransferase, is a chromatin regulator with oncogenic activity [14]. The methylating activity of SMYD3 on histone H3 lysine 4 (K4) in the
and the arginine methyltransferase PRMT1,211 Dot1 homologs exhibit methyltransferase specificity toward lysine rather than arginine.213,214,220 In this context, it will be interesting to determine whether Dot1 homologs methylate arginine rather than lysine residues, if present, on novel target proteins...
Mammalian cells express dozens of H3K9 methyltransferases containing catalytic SET domains flanked by pre-SET and post-SET domains; these include su(var)3-9 homolog 1 (SUV39H1)/KMT1A, SUV39H2/KMT1B, SET domain bifurcated histone lysine methyltransferase 1 (SETDB1)/KMT1E, G9a/euchromatic his...
Then, several other SET domain proteins have been shown to have methyltransferase activity toward specific lysine residues of histone tails but also to nonhistone proteins, such as the plant enzyme Rubisco (Trievel et al., 2002, Trievel et al., 2003), mammalian transcription factors (Chuikov ...
methylated lysine 9 of histone H3 serves as a binding site for the heterochromatin-associatedprotein HP1, which recruits a histonemethyltransferaseto the chromatin. This leads to the methylation of adjacent histone H3-lysine 9 residues, formation of additional HP1-binding sites, and spreading of the...
methyltransferase; DOT1L: disruptor of telomeric silencing 1-like; DZNep: 3-Deazaneplanocin A; EZH2: enhancer of zeste homologue 2; FAD: flavin adenine dinucleotide; FDA: Food and Drug Administration; HDAC: histone deacetylase; KDM: lysine demethylase; KMT: lysine methyltransferase; LSD1: lysine-...
Li Y, Reddy MA, Miao F, Shanmugam N, Yee JK, Hawkins D, et al. Role of the histone H3 lysine 4 methyltransferase, SET7/9, in the regulation of NF-kappaB-dependent inflammatory genes. Relevance to diabetes and inflammation. J Biol Chem. 2008;283:26771–81. Article CAS PubMed PubMed...
DOT1L and the arginine methyltransferase PRMT1,211Dot1 homologs exhibit methyltransferase specificity toward lysine rather than arginine.213,214,220In this context, it will be interesting to determine whether Dot1 homologs methylate arginine rather than lysine residues, if present, on novel target ...
DOT1L and the arginine methyltransferase PRMT1,211Dot1 homologs exhibit methyltransferase specificity toward lysine rather than arginine.213,214,220In this context, it will be interesting to determine whether Dot1 homologs methylate arginine rather than lysine residues, if present, on novel target ...
EHMT2 Euchromatic histone lysine N-methyltransferase 2 6p21.33 KMT1C, BAT8, C6orf30, GAT8, G9A, NG36 604599 Autism spectrum disorders (ASD); bladder cancer; lung cancer EZH1 Enhancer of zeste, Drosophila, homolog of, 1 17q21.2 KIAA0388, KMT6B 601674 Leukemia; thyroid cancer EZH2 Enhancer...