Mammalian cells express dozens of H3K9 methyltransferases containing catalytic SET domains flanked by pre-SET and post-SET domains; these include su(var)3-9 homolog 1 (SUV39H1)/KMT1A, SUV39H2/KMT1B, SET domain bifurcated histone lysine methyltransferase 1 (SETDB1)/KMT1E, G9a/euchromatic his...
219Despite structural similarities between human DOT1L and the arginine methyltransferase PRMT1,211Dot1 homologs exhibit methyltransferase specificity toward lysine rather than arginine.213,214,220In this context, it will be interesting to determine whether Dot1...
Lysine methylation, catalyzed by protein lysine methyltransferases (PKMTs), is a central post-translational modification regulating many signaling pathways. It has direct and indirect effects on chromatin structure and transcription. Accumulating evidence suggests that dysregulation of PKMT activity has a fu...
For example, methylated lysine 9 of histone H3 serves as a binding site for the heterochromatin-associated protein HP1, which recruits a histone methyltransferase to the chromatin. This leads to the methylation of adjacent histone H3-lysine 9 residues, formation of additional HP1-binding sites, ...
SET domain-containing histone methyltransferasesthat methylate H3K4 but are not closely related to yeast Set1/COMPASS have alsobeen identified and include MLL5, SET7 (also called SET9), SMYD1-3, SETMAR, andPRDM9 [6,15,24]. Table 1Subunit composition of H3K4 methyltransferase complexes in ...
EHMT2 Euchromatic histone lysine N-methyltransferase 2 6p21.33 KMT1C, BAT8, C6orf30, GAT8, G9A, NG36 604599 Autism spectrum disorders (ASD); bladder cancer; lung cancer EZH1 Enhancer of zeste, Drosophila, homolog of, 1 17q21.2 KIAA0388, KMT6B 601674 Leukemia; thyroid cancer EZH2 Enhancer...
and the arginine methyltransferase PRMT1,211 Dot1 homologs exhibit methyltransferase specificity toward lysine rather than arginine.213,214,220 In this context, it will be interesting to determine whether Dot1 homologs methylate arginine rather than lysine residues, if present, on novel target proteins...