Dual functions of histone-lysine N-methyltransferase Setdb1 protein at promyelocytic leukemia-nuclear body (PML-NB): Maintaining PML-NB structure and regulating the expression of its associated genes. J. Biol. Chem. 2011, 286, 41115-41124....
SETDB1 is a histone H3K9 methyltransferase that has a critical role in early development. It is located within a melanoma susceptibility locus and facilitates melanoma formation. However, the mechanism by which SETDB1 regulates tumorigenesis remains unknown. Here we report the molecular in...
Upregulation of histone methyltransferase SET domain bifurcated 1 (SETDB1) is associated with poor prognosis in cancer patients. However, the mechanism of oncogenicity of SETDB1 in cancer is hitherto unknown. Here, we show that SETDB1 is upregulated in human colorectal cancer (CRC) where its...
SETDB1 is an H3K9 methyltransferase that methylates histone H3 on lysine 9, up to tri-methylation (H3K9me3)16. It is recruited to the chromatin by the methyl-CpG-binding protein MBD1 (ref. 17) and silence genes including tumour suppressor genes, such as RASSF1A and P53BP2. In previous...
Gene amplification of the histone methyltransferase SETDB1 contributes to human lung tumorigenesis. Oncogene. 2014;33(21):2807–13. CentralRodriguez-Paredes M, Martinez de Paz A, Simo-Riudalbas L, Sayols S, Moutinho C, Moran S, Villanueva A, Vazquez-Cedeira M, Lazo PA, Carneiro F, Moura...
Histone methyltransferase TKI: Tyrosine kinase inhibitor KMT: Lysine methyltransferase PRMT: Protein arginine methyltransferase SAM: S-adenosyl-L-methionine Kme1: Lysine-monomethylation Kme2: Lysine-dimethylation Kme3: Lysine-trimethylation Rme1/MMA: N-monomethylarginine ADMA: Asymmetric dime...
Histone lysine methylation is pivotal in shaping the epigenetic landscape and is linked to cell physiology. Coordination of the activities of multiple histone lysine methylation modifiers, namely, methyltransferases and demethylases, modulates chromatin
DNA CpG methylation can cooperate with histone H3 lysine 9 (H3-K9) methylation in heterochromatin formation and gene silencing. Trimethylation of H3-K9 by the recently identified euchromatic histone methyltransferase SETDB1/ESET may be responsible for transcriptional repression of certain promoters. Here...
SETDB1transcriptional repression (tri-Me)(35) Dim-5(N. crassa), Kryptonite(A. thaliana)DNA methylation (tri-Me)(36,37) Ash1(D. melanogaster)transcriptional activation(30) Lys27Ezh2transcriptional silencing(38) X inactivation (tri-Me)
4.1Role of histone lysine methyltransferases in skin cancers 4.1.1SET domain family According to the type ofcatalytic domain,histonelysine methyltransferases are divided into two groups, including the SET-domain family and DOT1-like (DOT1L) lysinemethyltransferase[23]. The SET domain family is a gr...