Cho S, Park JS and Kang YK: Dual functions of histone-lysine N-methyltransferase Setdb1 protein at promyelocytic leukemia- nuclear body (PML-NB): Maintaining PML-NB structure and regulating the expression of
Subsets of endogenous retroviruses (ERVs) are derepressed in mouse embryonic stem cells (mESCs) deficient for Setdb1, which catalyzes histone H3 lysine 9 trimethylation (H3K9me3). Most of those ERVs, including IAPs, remain silent if Setdb1 is deleted in differentiated embryonic cells; however...
Histone methylation is one of the main epigenetic mechanisms by which methyl groups are dynamically added to the lysine and arginine residues of histone tails in nucleosomes. This process is catalyzed by specific histone methyltransferase enzymes. Methylation of these residues promotes gene expression reg...
The discovery of the first histone lysine methyltransferase was the result of bioinformatics, genetics, and biochemical approaches. The similarity of the SET domain to a plant methyltransferase is what prompted Jenuwein and colleagues to ask whether Su(var)3–9 was in fact a bona fide h...
SETDB1 is an H3K9 methyltransferase that methylates histone H3 on lysine 9, up to tri-methylation (H3K9me3)16. It is recruited to the chromatin by the methyl-CpG-binding protein MBD1 (ref. 17) and silence genes including tumour suppressor genes, such as RASSF1A and P53BP2. In previous...
Histone methylation refers to the occurrence of N-terminal arginine or lysine in H3 and H4 histones. Methylation at the residue of the amino acid is mediated by histone methyltransferase. The function of histone methylation is mainly reflected in heterochromatin formation, gene imprinting, and X ...
I tested the hypothesis that functions as a histone 3, lysine 9 (H3K9) histone methyltransferase (HMT), similar to SETDB1. I observed that is required for trimethylation of H3K9 in both germ and somatic cells of the ovary. Clonal analysis was performed to determine whether germ and somatic ...
has shown that KMT2A promotes leukemogenesis mainly through recruitment of MOF and forming H4K16ac (acetylation of lysine 16 of histone 4), not the intrinsic histone methyltransferase activity of KMT2A. However, the role of this mechanism in digestion cancers still needs further exploration.45 ...
The histone methyltransferase SETDB1 and the DNA methyltransferase DNMT3A interact directly and localize to promoters silenced in cancer cells. J Biol Chem. 2006;281:19489–500. 191. Suraweera A, O'Byrne KJ, Richard DJ. Combination therapy with histone deacetylase inhibitors (HDACi) for the ...
Schultz DC, Ayyanathan K, Negorev D, Maul GG, Rauscher FJ (2002)SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins.Genes Dev.16(8), 919–32. ...