n. any of a group of five small basic proteins, occurring in the nucleus of eukaryotic cells, that organize DNA strands into nucleosomes by forming molecular complexes around which the DNA winds. [< German Histon (1884) = hist- of uncertain orig. + -on, perhaps after Peptonpeptone] ...
Histone methyltransferase TKI: Tyrosine kinase inhibitor KMT: Lysine methyltransferase PRMT: Protein arginine methyltransferase SAM: S-adenosyl-L-methionine Kme1: Lysine-monomethylation Kme2: Lysine-dimethylation Kme3: Lysine-trimethylation Rme1/MMA: N-monomethylarginine ADMA: Asymmetric dime...
The methylation status of histones at different lysine residues is controlled by the reciprocal actions of specific histone lysine modifiers: histone lysine methyltransferases (KMTs) and histone lysine demethylases (KDMs) (Fig.1). The different activities of KMTs and KDMs in a given cellular context...
lysine methyltransferases that contain the SET domain and lysine methyltransferases that do not contain the SET domain, such as DOT1L. The SET domain lysine methyltransferases are further divided into several families: H3K4 KMTs (MLL1, MLL2, MLL3, MLL4, SET1A/SETD1A, and SET1B/SETD1B), ...
Lysine methylation, catalyzed by protein lysine methyltransferases (PKMTs), is a central post-translational modification regulating many signaling pathways
According to the type ofcatalytic domain,histonelysine methyltransferases are divided into two groups, including the SET-domain family and DOT1-like (DOT1L) lysinemethyltransferase[23]. The SET domain family is a group of proteins with methyltransferase activity on lysine residues. SET domain family...
KTMs, lysine methyltransferase; KDMs, lysine demethylases; PRMTs, protein arginine methyltransferases. Almost all the known KMTs have a 130-amino acid catalytic domain known as SET domain [Su (var), Enhancer of Zeste, and Trithorax], harboring the enzymatic activity [41]. The exception is DO...
Here we identify the histone H3 lysine 36 (H3K36) methyltransferase NSD3, the gene for which is located in the 8p11–12 amplicon, as a key regulator of LUSC tumorigenesis. In contrast to other 8p11–12 candidate LUSC drivers, increased expression of NSD3 correlated strongly with its gene ...
Schultz DC, Ayyanathan K, Negorev D, Maul GG, Rauscher FJ 3rd (2002) SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins. Genes Dev 16(8):919–932 Article PubMed ...
Protein arginine methyltransferase SAM: S-adenosyl-L-methionine Kme1: Lysine-monomethylation Kme2: Lysine-dimethylation Kme3: Lysine-trimethylation Rme1/MMA: N-monomethylarginine ADMA: Asymmetric dimethylarginine SDMA: Symmetric dimethylarginine MLL: ...