(a) At an early stage of transcription, C-terminal domain (CTD) phosphorylation at serine 5 recruits messenger RNA (mRNA) capping machinery and early termination factors. This modification also contributes to recruitment of Set1-COMPASS that methylates histone H3 at lysine 4 in 5′ transcribed ...
Epigenetic regulatory mechanisms, including DNA methylation, histone modification, chromatin remodeling, and microRNA expression, play critical roles in cell differentiation and organ development through spatial and temporal gene regulation. Neurogenesis is a sophisticated and complex process by which neural st...
Consistent with the binding specificity of the RAG2 PHD finger, high levels of H3R2me2sK4me3 are found at antigen receptor gene segments ready for rearrangement. However, this double modification is much more general; it is conserved throughout eukaryotic evolution. In mouse, H3R2me2s is ...
Chromatin regulates gene expression and genome maintenance, and consists of histones and other components. The post translational modification of histones plays a key role in maintaining the structure and function of chromatin under different pathophysiological stress conditions. Here, we investigate the ...
Histone modification in the pathogenesis of depression In eukaryotic cells, nucleosomes constitute the fundamental repeating structural units of chromatin, wherein core histones (H2A, H2B, H3, and H4) and histone-associated proteins are packaged together with DNA. Histone modifications play a role in...
methylation [4]. However, it remained unclear how H3K4me3 modification influences the gene expression of the sperm cell lineage and the VC. Here, based on our previously established procedure [37], we isolated microspores and nuclei of GCs, SCs, and VC at high purity and obtained epigenomic ...
During male gametogenesis of flowering plants, sperm cell lineage (microspores, generative cells, and sperm cells) differentiated from somatic cells and acquired different cell fates. Trimethylation of histone H3 on lysine 4 (H3K4me3) epigenetically cont
An important mechanism for gene regulation involves chromatin changes via histone modification. One such modification is histone H3 lysine 4 trimethylation... PL Sílvia,B Enrique,C Albert,... - 《Nucleic Acids Research》 被引量: 177发表: 2011年 Repression of FLOWERING LOCUS T Chromatin by Functi...
Metabolic regulation of gene expression by histone lysine β-hydroxybutyrylation. Mol. Cell 62, 194–206 (2016). A study that reports Kbhb as a new type of histone modification that is closely associated with ketone body metabolism. Article CAS PubMed PubMed Central Google Scholar Choudhary,...
Ectopic expression of PADI4 also induced the citrullination of at least two core histones (Fig. 1c). To further characterize this modification, purified histones were treated with recombinant PADI4. Antibodies against specific citrulline residues (cit-H3R2,8,17 or cit-H4R3) as well as anti-MC...