Background:Modulation of the chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of four core histone proteins (H2A, H2B, H3 and H4), is the pri
Background:Modulation of the chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of four core histone proteins (H2A, H2B, H3 and H4), is the primary building block of chromatin. The N-terminal tail of core histones undergoes dif...
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limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones,...
Modulation of the chromatin structureAnti-Histone H3 (acetyl K9, phospho S10)抗体plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of four core histone proteins (H2A, H2B, H3 and H4), is the primary building block of chromatin. The N-terminal ...
Sequence similaritiesBelongs to the histone H3 family. Developmental stageExpressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation. Post-translationalmodificationsAcetylation is generally linked to gene activation. Acetylation on Lys-10 (H3...
regulation,DNArepair,DNAreplicationandchromosomalstability.DNAaccessibilityisregulatedviaacomplex setofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling. SequencesimilaritiesBelongstothehistoneH3family. DevelopmentalstageExpressedduringSphase,thenexpressionstronglydecreasesascelldivisionslowsdow...
Histone acetylation occurs primarily at multiple lysine residues on the amino-terminal of core histones, in response to various stimuli and plays vital roles in the regulation of gene expression, DNA damage repair, chromatin dynamics, etc. Mostly, histone H2A is primarily acetylated at Lys5, 9, ...
Gene expression profile following treatment with VPA at 2 and 5 mM showed down-regulation of genes involved in cell cycle regulation, DNA replication and transcription as well as up-regulation of genes implicated in apoptosis and chemokine pathways. The signaling pathway analysis performed by ...
The link could be direct, such as through deposition of the same histone marks (including H3K9me3) at memory and ISGs loci. H3K9me3 could also control ISGs indirectly, for example through regulation of expression of transposable elements (TEs), which in turn drive IFN-signaling. Indeed, Suv...