组成与结构 Histone H3: 作用: 组蛋白 H3 是核小体的主要成分之一,参与 DNA 包装和基因调控。 K14: 第14 位赖氨酸: 赖氨酸是带正电荷的氨基酸,能够与带负电荷的 DNA 发生强烈的静电相互作用。 Acetylation (Ac): 乙酰化修饰: 乙酰化是将乙酰基(CH3CO-)添加到赖氨酸的ε-氨基上。这一修饰中和了赖氨酸的...
BRPF3-HBO1 regulates replication origin activation and histone H3K14 acetylation. EMBO J 2016;35:176-92. https://doi.org/10.15252/embj.201591293.Feng, Y., Vlassis, A., Roques, C., Lalonde, M. E., Gonzalez-Aguilera, C., Lambert, J. P., Lee, S. B., Zhao, X., Alabert, C....
Histone H3K14Ac (9-19) is a peptide fragment of histone H3 that corresponds to amino acid residues 10-20 of the human histone H3 sequence. Acetylation of H3K14 is associated with transcriptional activation and is required for trimethylation of H3K4. Histone H3K14Ac (9-19) has been used ...
ENAP1 gain-of-function mutants display hyperacetylation of H3K14 and H3K23. Moreover, we found that EIN3 can interact with ENAP1. Although up-regulation of histone acetylation in response to ethylene is not EIN3/EIL1 dependent, transcription activation in the presence of ethylene is fully ...
Acetylation by PCAF enhances CIITA nuclear accumulation and transactivation of major histocompatibility complex class II genes. Mol. Cell. Biol. 2000; 20 :... S Suwankawin,S Sangwongwanich - 《Molecular & Cellular Biology》 被引量: 372发表: 2000年 PCAF Interacts with Tax and Stimulates Tax ...
Product DescriptionRabbit monoclonal to Acetylated Histone H3 Lysine 14 (K14ac), H3K14ac, Histone H3 (K14 acetylation) Catalog No.31-1032-00 Clone NameRM130 Product Data SheetAnti-Acetyl-Histone H3 Lys14 Rabbit Monoclonal Antibody Data Sheet RM130 ...
U. Emerging connections between DNA methylation and histone acetylation. Cell. Mol. Life Sci. 58, 721–727 (2001). Article CAS PubMed Google Scholar Coleman, R. T. & Struhl, G. Causal role for inheritance of H3K27me3 in maintaining the OFF state of a Drosophila HOX gene. Science ...
made up of DNA wound around eight core histone proteins (two each of H2A, H2B, H3, and H4), is the primary building block of chromatin (1). The amino-terminal tails of core histones undergo various post-translational modifications, including acetylation, ...
(1).Histone H3is primarily acetylated at lysines 9, 14, 18, and 23 and have a theoretical molecular weight of 15 kDa. Acetylation at lysine 9 and 14 appears to control histone deposition, chromatin assembly and active transcription. Methylation of arg...
At the single nucleosome level, removal of the H3 and H4 N-terminal tails destabilizes the nucleosome structure and increases DNA exposure12,13,14,15,16. The acetylation of H3 enhances DNA unwrapping17. Deletion or alanine mutation of H3NtT promotes nucleosome sliding along the DNA15. As the...