Histone H3: 作用: 组蛋白 H3 是核小体的主要成分之一,参与 DNA 包装和基因调控。 K14: 第14 位赖氨酸: 赖氨酸是带正电荷的氨基酸,能够与带负电荷的 DNA 发生强烈的静电相互作用。 Acetylation (Ac): 乙酰化修饰: 乙酰化是将乙酰基(CH3CO-)添加到赖氨酸的ε-氨基上。这一修饰中和了赖氨酸的正电荷,减弱...
BRPF3-HBO1 regulates replication origin activation and histone H3K14 acetylation. EMBO J 2016;35:176-92. https://doi.org/10.15252/embj.201591293.Feng, Y., Vlassis, A., Roques, C., Lalonde, M. E., Gonzalez-Aguilera, C., Lambert, J. P., Lee, S. B., Zhao, X., Alabert, C....
ENAP1 gain-of-function mutants display hyperacetylation of H3K14 and H3K23. Moreover, we found that EIN3 can interact with ENAP1. Although up-regulation of histone acetylation in response to ethylene is not EIN3/EIL1 dependent, transcription activation in the presence of ethylene is fully ...
Histone H3K14Ac (9-19) is a peptide fragment of histone H3 that corresponds to amino acid residues 10-20 of the human histone H3 sequence. Acetylation of H3K14 is associated with transcriptional activation and is required for trimethylation of H3K4. Histone H3K14Ac (9-19) has been used ...
Histone acetylation is associated with regions of active transcription and is thought to be a more dynamic mark than methylation [7]. Acetylation of most histone residues decreases during mitosis [101,102,111], although H3K14ac may be more stable [20,101,102], and active promoters may retain...
U. Emerging connections between DNA methylation and histone acetylation. Cell. Mol. Life Sci. 58, 721–727 (2001). Article CAS PubMed Google Scholar Coleman, R. T. & Struhl, G. Causal role for inheritance of H3K27me3 in maintaining the OFF state of a Drosophila HOX gene. Science ...
Product NameAnti-Acetyl-Histone H3 (Lys14) Rabbit MonoclonalAntibody[RM130] Product DescriptionRabbit monoclonal to Acetylated Histone H3 Lysine 14 (K14ac), H3K14ac, Histone H3 (K14 acetylation) Catalog No.31-1032-00 Clone NameRM130
The HAT activity of SRC-1 maps to its carboxy-terminal region and is primarily specific for histones H3 and H4. Acetylation by SRC-1 and PCAF of ... TE Spencer,G Jenster,MM Burcin,... - 《Nature》 被引量: 3119发表: 1997年 Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300...
(1).Histone H3is primarily acetylated at lysines 9, 14, 18, and 23 and have a theoretical molecular weight of 15 kDa. Acetylation at lysine 9 and 14 appears to control histone deposition, chromatin assembly and active transcription. Methylation of arg...
Acetylation of histone H3K23 has emerged as an essential posttranslational modification associated with cancer and learning and memory impairment, yet our understanding of this epigenetic mark remains insufficient. Here, we identify the native MORF compl