(2012) Mechanisms of histone H3 lysine 27 trimethylation remodeling 32 during early mammalian development. Epigenetics 7, 976-981.Bogliotti YS, Ross PJ (2012) Mechanisms of histone H3 lysine 27 trimethylation remodeling during early mammalian development. Epigenetics 7:976–981...
Histone H3 lysine 27 trimethylationPrunus persica (peach)Bud dormancy is an evolutionary adaptation of perennial plants to the seasonal fluctuation of temperatures in temperate climates, affected by intrinsic and environmental signals. Recent investigations point to a relevant role of epigenetic mechanisms ...
Although histone H3 lysine 27 trimethylation (H3K27Me3) is associated with gene silencing, whether H3K27Me3 demethylation affects transcription and cell differentiation in vivo has remained elusive. To investigate this, we conditionally inactivated the two H3K27Me3 demethylases, Jmjd3 and Utx, in...
[7]. Common histone modifications leading to gene silencing in prostate cancer include histone H3 lysine 9 methylation (H3K9me3), histone deacetylation, and polycomb-based histone H3 lysine 27 trimethylation (H3K27me3) [8]. Polycomb-mediated H3K27me3 has been shown to play critical role in ...
It has been suggested that trimethylation of lysine 27 on histone H3 (H3K27me3) is a crucial epigenetic process in tumorigenesis. However, the expression d... Cai, Mu-Yan,Hou, Jing-Hui,Rao, Hui-Lan,... - 《Molecular Medicine》 被引量: 166发表: 2011年 Structural basis of histone H3...
This study investigates the epigenetic regulation of this process, focusing on the marks histone H3 lysine 27 trimethylation (H3K27me3) and its deposition genes during the chilling-induced floral induction (FId) and initiation stages. Our genomic analysis delin...
Evaluation of Histone 3 Lysine 27 Trimethylation (H3K27me3) and Enhancer of Zest 2 (EZH2) in Pediatric Glial and Glioneuronal Tumors Shows Decreased H3K27m... Evaluation of histone 3 lysine 27 trimethylation (H3K27me3) and enhancer of Zest 2 (EZH2) in pediatric glial and glioneuronal ...
Polycomb group (PcG)-mediated histone H3 lysine 27 trimethylation (H3K27me3) has a key role in gene repression and developmental regulation1,2,3,4. There is evidence that H3K27me3 is actively removed in plants5,6,7,8, but it is not known how this occurs. Here we show that RELATIVE...
Histone H3 Lysine 27 (H3K27) methylation is correlated with transcription repression. Recently study has found that GSK126, a histone methyltransferase EZH2 inhibitor, decreases global H3K27me3 levels and effectively inhibits the proliferation of EZH2 mutant DLBCL cell lines (1). Small molecule EPZ...
Wei Y,Xia W,Zhang Z, et al.Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers. Molecular Carcinogenesis . 2008Wei Y, Xia W, Zhang Z, et al. Loss of trimethylation at lysine 27 of histone H3 is a predictor of...