DNA histone interaction refers to the process where histone modifications, such as acetylation and methylation, influence the structure of chromatin by altering the accessibility of transcriptional regulators to DNA-binding elements. AI generated definition based on: Trends in Pharmacological Sciences, 2015...
This interaction is maximal for the 202 base-pair repeat and suggests a co-operative mechanism for the formation of ordered nucleosomal arrays based on a combination of DNA flexibility and nucleosome-nucleosome interactions.doi:10.1016/S0022-2836(05)80061-0Thomas E. Shrader...
Given the chemical similarities between lactylation and acetylation10,31, it is likely that the former also weakens the interaction between histones and DNA32,33, and increases the efficiency with which RNAPII moves through chromatin in vitro34. Indeed, histone acylations (e.g., acetylation, ...
Histone H5 has been labelled with fluorescein isothiocyanate (FITC) with particular attention to the reaction conditions (pH, reaction time and input FITC/H5 molar ratio) and to the complete elimination of non-covalently bound dye. We preferred to use reaction conditions which yielded non-specific ...
Histones have been both radiolabeled and density-labeled with amino acids in vivo to determine the dynamics of histone-DNA and histone-histone interactions at the replication fork and on active genes. Proteins were uniformly labeled and subsequently chased for three cell generations. During the chase...
Chromatin challenges during DNA replication and repair. Cell 128, 721–733 (2007). Article CAS PubMed Google Scholar Huen, M.S.Y., Sy, S.M.-H., van Deursen, J.M. & Chen, J. Direct interaction between SET8 and proliferating cell nuclear antigen couples H4–K20 methylation with DNA...
In this paper, tapping mode atomic force microscopy was applied to visualize the higher order chromatin structure reconstituted from calf thymus DNA and ca... D Liu,W Chen,J Li,... - 《Surface & Interface Analysis》 被引量: 13发表: 2010年 Interaction between Nonhistone Protein HMGB1 and Li...
Structure and function of DnaA N-terminal domains: specific sites and mechanisms in inter-DnaA interaction and in DnaB helicase loading on oriC. DnaA forms a homomultimeric complex with the origin of chromosomal replication (oriC) to unwind duplex DNA. The interaction of the DnaA N terminus ...
摘要: Histone PTMs and DNA modifications coordinately regulate chromatin function.Newly revealed modifications add distinct elements of regulatory control on the chromatin template.Aided by new technologies, a newfound appreciation for the complexities of DNA and histone recognition is emerging....
Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins. Members of the heterochromatin protein 1 (HP1) family are silencing nonhistone proteins. Here, we show that in P19 embryonal carcinoma (EC) nuclei, HP1 α,... A.L. Nielsen,M Oulad-Abdelghani,J.A....