Till date, there has not been much progress in studying various epigenomic marks in common bean, and therefore, the long-term objective of this research is to identify protein-DNA interaction sites in the common bean genome to include histones, as well as, non-histone proteins such as ...
DNA histone interaction refers to the process where histone modifications, such as acetylation and methylation, influence the structure of chromatin by altering the accessibility of transcriptional regulators to DNA-binding elements. AI generated definition based on:Trends in Pharmacological Sciences,2015 ...
Histone H5 has been labelled with fluorescein isothiocyanate (FITC) with particular attention to the reaction conditions (pH, reaction time and input FITC/H5 molar ratio) and to the complete elimination of non-covalently bound dye. We preferred to use reaction conditions which yielded non-specific ...
The circular dichroism of DNA near 275 nm is depressed by the interaction with (H2A, H2B) at low concentrations of salt. The depression increases with increasing amounts of (H2A, H2B), and reaches a plateau at an (H2A, H2B) to DNA ratio of 1.5 ( w w), at which one (H2A, H2B) ...
Given the chemical similarities between lactylation and acetylation10,31, it is likely that the former also weakens the interaction between histones and DNA32,33, and increases the efficiency with which RNAPII moves through chromatin in vitro34. Indeed, histone acylations (e.g., acetylation, ...
Chromatin challenges during DNA replication and repair. Cell 128, 721–733 (2007). Article CAS PubMed Google Scholar Huen, M.S.Y., Sy, S.M.-H., van Deursen, J.M. & Chen, J. Direct interaction between SET8 and proliferating cell nuclear antigen couples H4–K20 methylation with DNA...
In addition,histoneexchange reveals new changing mechanism of DNA -histoneinteraction. 并且, 组蛋白替换揭示了DNA - 组蛋白相互作用变化的一种新的机制. 互联网 Histonemodifications are implicated in influencing gene expression. 组蛋白修饰与影响基因表达有关. ...
DNMT1 is recruited by PCNA and UHRF1 to maintain DNA methylation after replication. UHRF1 recognizes hemimethylated DNA substrates via the SRA domain, but also repressive H3K9me3 histone marks with its TTD. With systematic mutagenesis and functional assa
Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination (By similarity). Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair ...
Accurate and complete replication of the genome is essential not only for genome stability but also for cell viability. However, cells face constant threats to the replication process, such as spontaneous DNA modifications and DNA lesions from endogenous