Structure and function of histone chaperones in replication-coupled chromatin assemblyDNA replicationNucleosome assemblyHistone chaperonesHistone recyclingEukaryotic cell divisions pass on genetic and epigenetic
Publications Platonova, Olga; Akey, Ildikó V; Head, James F et al. (2011) Crystal structure and function of human nucleoplasmin (npm2): a histone chaperone in oocytes and embryos. Biochemistry 50:8078-89 Comments Be the first to comment on Christopher Akey's grant ©...
(D) Overall structure of the BRD4(1) BRD. N and C termini and secondary structure elements are labeled. See also Figure S1. Table 1. Human Bromodomain Family ProteinNameAliasProtein FunctionSubcellular LocalizationaUniProt IDReference ASH1L ash1 (absent, small, or homeotic)-like ASH1, KMT2H...
Structure data have been deposited in Protein Data Bank under accession numbers 4N4G (free bromo–PWWP), 4N4H (bromo–PWWP–H3.1K36me3 complex) and 4N4I (bromo–PWWP–H3.3K36me3 complex). The ChIP-seq and RNA-seq data been deposited in the Gene Expression Omnibus database under access...
Kinetics of core histones in living human cells: little exchange of H3 and H4 and some rapid exchange of H2B. J. Cell Biol. 153, 1341–1353 (2001). Article CAS PubMed PubMed Central Google Scholar Wolffe, A. P. Chromatin: Structure and Function, 3rd edn. (Academic Press, 1998). ...
Methylation of histones has associated with chromatin since long, and the histone methyltransferases since their discovery have been tied solely to chromatin structure and function by influencing transcriptional activation and repression in mammalian cells. Targeting these enzymes tied to histone methylation ...
Many different histone modifying enzymes contribute to the dynamic regulation of chromatin structure and function, with concomitant impacts on gene transcription. For example, the balance of Histone acetyltransferase (HAT) and Histone deacetylase (HDAC) activities that are associated with any given gene ...
Structure of the HDAC6 gene and protein. The gene-encoding HDAC6 is located in Xp11.23 (left). The HDAC6 protein (right) contains two functional catalytic domains (DD1 and DD2), which catalyze deacetylation activity for α-tubulin, HSP90, and cortactin. The nuclear export signal (NES) pr...
To study whether Kbu had a function to poise gene activation by internal signals, we identified genes that displayed circadian expression in the rice seedlings at four diurnal time points by RNA-seq (Additional file 1: Table S2) and also analyzed H3K9ac by ChIP-seq of the samples (Additional...
structureby regulating acetylation of core histone proteins.Deacetylationof histones is thus associated with compacting the DNA and repressing transcription. Inlung cancer cell lines, for example, deacetylation ofhistone 3correlated with refractoriness toretinoic acid, a phenomenon related to RARbeta ...