Bondarenko, M.T.; Maluchenko, N.V.; Valieva, M.E.; Gerasimova, N.S.; Kulaeva, O.I.; Georgiev, P.G.; Studitsky, V.M. Structure and function of histone chaperone FACT. Mol. Biol. (Mosk.) 2015, 49, 891-904. [CrossRef] [PubMed]...
Publications Platonova, Olga; Akey, Ildikó V; Head, James F et al. (2011) Crystal structure and function of human nucleoplasmin (npm2): a histone chaperone in oocytes and embryos. Biochemistry 50:8078-89 Comments Be the first to comment on Christopher Akey's grant ©...
This modification involves the addition of a methyl group (CH3) to the lysine residue, thereby altering the chromatin structure and function, thus regulating chromatin organization and accessibility, ultimately influencing gene expression and other cellular processes [111]. Frequently encountered histones ...
(D) Overall structure of the BRD4(1) BRD. N and C termini and secondary structure elements are labeled. See also Figure S1. Table 1. Human Bromodomain Family ProteinNameAliasProtein FunctionSubcellular LocalizationaUniProt IDReference ASH1L ash1 (absent, small, or homeotic)-like ASH1, KMT2H...
Structure data have been deposited in Protein Data Bank under accession numbers 4N4G (free bromo–PWWP), 4N4H (bromo–PWWP–H3.1K36me3 complex) and 4N4I (bromo–PWWP–H3.3K36me3 complex). The ChIP-seq and RNA-seq data been deposited in the Gene Expression Omnibus database under access...
Eskeland, R. et al. Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination. Mol. Cell 38, 452–464 (2010). Article CAS PubMed PubMed Central Google Scholar Plys, A. J. et al. Phase separation of Polycomb-repressive complex 1 is governed by...
Methylation of histones has associated with chromatin since long, and the histone methyltransferases since their discovery have been tied solely to chromatin structure and function by influencing transcriptional activation and repression in mammalian cells. Targeting these enzymes tied to histone methylation ...
Many different histone modifying enzymes contribute to the dynamic regulation of chromatin structure and function, with concomitant impacts on gene transcription. For example, the balance of Histone acetyltransferase (HAT) and Histone deacetylase (HDAC) activities that are associated with any given gene ...
Structure of the HDAC6 gene and protein. The gene-encoding HDAC6 is located in Xp11.23 (left). The HDAC6 protein (right) contains two functional catalytic domains (DD1 and DD2), which catalyze deacetylation activity for α-tubulin, HSP90, and cortactin. The nuclear export signal (NES) pr...
‘core’ histones (H2A, H2B, H3 and H4) are relatively similar in structure and are highly conserved in evolution, all featuring a 'helix turn helix turn helix' motif (which allows the easy dimerization). Histone tails are mobile and highly basic which is essential for theirinteraction with ...