Structure of the histone-like protein H-NS and its role in regulation and genome - Rimsky () Citation Context ...ligomers bridging the segments of DNA in vitro, and the bridging of DNA segments by H-NS is proposed to play a role in nucleoid organization in vivo by maintaining negatively...
The FACT protein is an essential type of histone chaperone. These guardian proteins escort other proteins during the deconstruction and reconstruction of nucleosomes, or the structural unit responsible for organizing and packaging DNA. This happens during gene transcription (the step where DNA is co...
automated sequence analyses of large fragments obtained by staphylococcal protease digestion of histone H2A and by limited hydrolysis of H2A-H2B complex with mouse submaxillary gland protease and from structural studies of peptides generated by enzymatic hydrolyses of these fragments or of the protein.DO...
7.1.2 Outline the structure of nucleosomes. Nucleosomes consist of DNA wrapped around eight histoneproteinsand held together by another histone protein. 7.1.3 State that nucleosomes help to supercoil chromosomes and help to regulate transcription. Nucleosomes help to supercoil chromosomes and help r...
Structure and mechanism of human diacylglycerol O-acyltransferase 1. Nature 581, 329–332 (2020). CAS PubMed PubMed Central Google Scholar Dutnall, R. N., Tafrov, S. T., Sternglanz, R. & Ramakrishnan, V. Structure of the histone acetyltransferase Hat1: a paradigm for the GCN5-...
A critical strategy for the regulation of polyamine function is reversible acetylation. This strategy is analogous to the regulation of protein function by reversible lysine acetylation through reactions catalysed by histone acetyltransferases and histone deacetylases (HDACs, also known more generally as lys...
Protein - Muscle, Structure, Function: The total amount of muscle proteins in mammals, including humans, exceeds that of any other protein. About 40 percent of the body weight of a healthy human adult weighing about 70 kilograms (150 pounds) is muscle, w
The linker histone protein has a globular domain and two unstructured tails. The N-terminal domain (NTD) is short, and the C-terminal domain (CTD) is half the size of the whole molecule and is enriched in basic residues13(Fig.1B). The structure of the globular domain has been solved ...
Over two decades ago, the crystal structure of the nucleosome revealed that the histone octamer, consisting of a histone H3-H4 tetramer and two H2B-H2A dimers, forms a stable protein spool that binds and wraps DNA into almost two rotations around a central axis (Luger et al., 1997). This...
Figure 1. Domain Structure of the Sos Protein (A) Boundaries of the domains of Sos. The construct used for structure determination consists of residues 1–191 of human Sos1, denoted “Histone domain.” PxxP motifs are SH3 domain binding sites. DH domains are found in GDP/GTP exchange fact...