In plants, RNA-directed DNA methylation (RdDM) is a well-known de novo DNA methylation pathway that involves two plant-specific RNA polymerases, Pol IV and Pol V. In this study, we discovered and characterized an RdDM factor, RDM15. Through DNA methylome
The histone-like nucleoid structuring (H-NS) protein is a DNA binding factor, found in gammaproteobacteria, with functional equivalents in diverse microbes. Universally, such proteins are understood to silence transcription of horizontally acquired genes. Here, we identify transposon capture as a major...
Purification and subsequent analyses demonstrated that the 10-kDa protein is HBsu, which was originally identified as a member of the histone-like protein family. By constructing a HBsu-deficient B. subtilis mutant, we showed that HBsu is essential for normal growth. Immunoprecipitating cell ...
a组蛋白是存在于染色体内的与DNA结合的碱性蛋白质,染色体中组蛋白以外的蛋白质成分称非组蛋组蛋白。绝大部分非组蛋白呈酸性,因此也称酸性蛋白质或剩余蛋白质。 The histone is exists in the chromosome with the DNA union alkalinity protein, in the chromosome outside the histone protein ingredient calls the...
The maternal histone H1 variant, H1M (B4 protein), is the predominant H1 histone in Xenopus pregastrula embryos. The Xenopus laevis H1M protein (formerly called B4) is a maternally inherited histone H1 subtype restricted in its expression to early development. Levels... E Dworkin-Rastl,H Kan...
Histone usually contain 5 ingredients such as H1,H2A,H2B,H3,H4. Addition to H1, while the other 4 kinds of histone is a Dimer of each (total of eight Dimer) combined to form a nucleosome core. DNA is wrapped around the nucleosome core. ...
We further show that the supercomplex is associated with the promoter of an ALL-1 target gene and induces histone modifications in this region. Results Posttranslational Processing of the ALL-1 Protein The ALL-1 gene encodes a protein of 3969 residues with an expected mass of ∼430 kDa (...
Acetylation of histone lysine residues correlates with transcription activation, but it is currently debated whether histone acetylation is a cause or a consequence of transcription. Here, the authors show how global protein acetylation remains unaltered after acute inhibition of transcription, indicating ...
Furthermore, AREB1:RD plants displayed reduced survival under dehydration, and three of the eight greatly upregulated genes were downregulated, including genes for linker histone H1 and AAA ATPase, which govern gene expression and multiple cellular activities through protein folding, respectively. Thus,...
Despite recent advances in therapeutic approaches, patients with MLL-rearranged leukemia still have poor outcomes. Here, we find that the RNA-binding protein IGF2BP3, which is overexpressed in MLL-translocated leukemia, strongly amplifies MLL-Af4-mediate