Notably, a wide spectrum of proteins on apical and basal domains or within the cell junction complexes have been reported to be upstream mediators of the Hippo pathway cascade.60For example, inDrosophila, the tumour suppressor Merlin/neurofibromin-2 (Mer/NF2) localizes at the apical domain and...
Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2. Cell 154, 1342–1355 (2013). Article CAS PubMed Google Scholar Nishio, M. et al. Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice. J. Clin. Invest. ...
(Merlin) is connected to the junctional proteins PATJ and PALS1 via AMOT, showed negative regulation of another tight junction-associated Rich1/AMOT/PATJ/PALS1 complex in response to environmental signals (Yi et al., 2011). Accordingly, the tight junction fraction of YAP or TAZ was increased...
Hippo Signaling Pathway Dysregulation in Human Huntington's Disease Brain and Neuronal Stem Cells The Hippo signaling pathway is involved in organ size regulation and tumor suppression. Although inhibition of Hippo leads to tumorigenesis, activation of Hippo may play a role in neurodegeneration. Specifica...
Together, these studies established the Hippo signaling pathway as a linear kinase cascade targeting Yki-Sd to regulate tissue growth. Additional components, Merlin (Mer) and kidney and brain protein (Kibra, Kbr), were also identified as important upstream regulators of the pathway.18,19,20,21 ...
always dependent on MST1/2 and LATS1/2. MST1/2 and LATS1/2 play various YAP1/TAZ-independent roles, while YAP1 and TAZ cross-talk with other signaling pathways. In this review we focus on YAP1 and TAZ and discuss their regulation, function, and the consequences of their dysregulation....
Iron metabolism dysregulation is tightly associated with cancer development. But the underlying mechanisms remain poorly understood. Increasing evidence has shown that long noncoding RNAs (lncRNAs) participate in various metabolic processes via integrati
Hippo通路在原发性肝癌发生发展中的作用 洪莹晖
Yu, J. et al. Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and expanded.Dev. Cell18, 288–299 (2010). ArticleCASPubMedPubMed CentralGoogle Scholar Tyler, D. M. & Baker, N. E. Expanded and Fat regulate growth and differentiation ...
Inactivation of Merlin in malignant mesothelioma cells and the Hippo signaling cascade dysregulation. Pathol. Int. 61, 331–344 (2011). CAS PubMed Google Scholar Mizuno, T. et al. YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle-promoting genes. ...