Early radiotherapy after radical prostatectomy improves cancer-specific survival only in patients with highly aggressive prostate cancer: validation of recently released criteria. Int J Urol 2015;22:89-95.Gandaglia G, Karakiewicz PI, Briganti A, et al. Early radiotherapy after radical prostatectomy ...
This is basically in line with our finding of higher HDAC levels in more aggressive tumours, even though the tumours of our cohort represent untreated primaries, most of which are supposedly hormone-naïve. Apart from a study on HDAC1 and HDAC3 expression in breast cancer describing an ...
In addition, circulating miR-1246 has been suggested as a biomarker for diagnosing and predicting the outcomes in pancreatic cancer [43, 44], esophageal squamous cell carcinoma [45], lung cancer [46, 47], aggressive prostate cancer [48], and melanoma [49]. In the latter, high levels of ...
Investigating the underlying mechanisms of sex differences in RCC could provide valuable insights into the biological basis of gender disparities in cancer. In this study, we found that the malignant cells in male tumors were more aggressive and angiogenic than in female tumors, which was consistent...
Recognition of these unique morphologic features could help identify IDH1-mutant prostate cancer cases retrospectively and prospectively-facilitating future large research studies and enabling clinical trial enrollment and precision medicine approaches for patients with advanced and/or aggressive disease.(c) ...
Molecular apocrine breast cancers are aggressive estrogen receptor negative tumors overexpressing either HER2 or GCDFP15. Breast Cancer Res. 2013;15:R37. Article CAS PubMed PubMed Central Google Scholar Farmer P, Bonnefoi H, Becette V, Tubiana-Hulin M, Fumoleau P, Larsimont D, et al. ...
et al. In1-ghrelin splicing variant is overexpressed in pituitary adenomas and increases their aggressive features. Scientific reports 5 (2015). 43. Hanahan, D. & Weinberg, R. A. The hallmarks of cancer. Cell 100, 57–70 (2000). 44. Bracken, A. P. et al. EZH2 is downstream of the...
25 Additionally, the PLD2 location (17p13) is situated in an area of chromosome 17 that, besides being involved in brain and eye development and in somatic growth, is also found to be frequently altered in breast cancers and contributes to high S-phase, higher aggressive tumor phenotype, ...
As used herein, the terms “advanced prostate cancer”, “locally advanced prostate cancer”, “advanced disease” and “locally advanced disease” mean prostate cancers that have extended through the prostate capsule, and are meant to include stage C disease under the American Urological Association ...
We and others previously reported of associations of class I HDACs with more aggressive tumours and even shortened patient survival in prostate cancer and gastric cancer [7, 8, 29]. In our cohort we could not find relevant and significant associations of the HDAC expression with tumour grade an...