Aggressive variant prostate cancer (AVPC) is a clinically defined tumor with neuroendocrine or small-cell differentiation, visceral metastases, low prostate-specific antigen, androgen receptor insensitivity, and poor response to androgen-deprivation or platinum-based chemotherapy. ...
Found, the Genes That Lead to Most Aggressive Type of Prostate Cancer
Dr. Amar Kishan. Credit: University of California, Los Angeles Researchers at the UCLA Jonsson Comprehensive Cancer Center analyzed gene-expression patterns in the most aggressive prostate cancer grade group—known as Gleason grade group 5—and found that this grade of cancer can actually be subdivid...
Prostate cancer is a type of malignancy that arises in the prostate gland. Prostate cancer tends to develop in older men, aged 50 and over. In many cases prostate cancer develops slowly, although in some cases it can be aggressive and metastasize to other parts of the body.Latest...
prostate cancer with low AR-activity (AR-A; based on a signature of nine canonical AR transcriptional targets) experience a shorter time to recurrence34. Thus, we next sought to determine if MYC transcriptional activity status in low AR-A tumors could identify a more aggressive subtype of ...
while those from the transition zone are less aggressive. The pathologic evaluation of biopsied prostate tissue is traditionally done using Gleason Scoring. The microscopic evaluation of prostate tissue with careful histologic grading is very important factor in assessing the outcomes in prostatic cancer....
A subset of patients with advanced castration-resistant prostate cancer may eventually evolve into an androgen receptor (AR)-independent phenotype, with a clinical picture associated with the development of rapidly progressive disease involving visceral sites and hormone refractoriness, often in the setting...
being the most aggressive cancer cell type. The Gleason score is based on the sum of these two numbers (tissue grade and cell type grade). A Gleason score of 5 + 5 = 10 indicates a highly aggressive prostate tumor while a low score (2 + 2 = 4) indicates a less aggressive cancer. ...
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Furthermore, we demonstrate that the expression of PHF8 is induced by hypoxia in various prostate cancer cell lines. Knockdown of either hypoxia-inducible factor HIF2α or HIF1α almost completely abolished hypoxia-induced PHF8 expression. Importantly, we observed that PHF8 is highly expressed in ...