Primary fallopian tube high-grade serous carcinoma (HGSCa) has historically been considered an uncommon neoplasm. Recent evidence, however, suggests that most extrauterine HGSCa arise within the fimbriae of the fallopian tube, via an intraepithelial precursor lesion known as serous tubal intraepithelial...
High-grade serous carcinoma (HGSC) is the most prevalent and aggressive subtype of ovarian cancer. The large degree of clinical heterogeneity within HGSC has justified deviations from the traditional one-size-fits-all clinical management approach. However, the majority of HGSC patients still relapse w...
High-grade serous ovarian carcinoma (HGSOC) is the most frequent type of ovarian cancer and has a poor outcome. It has been proposed that fallopian tube cancers may be precursors of HGSOC but evolutionary evidence for this hypothesis has been limited. Here, we perform whole-exome sequence and...
Ovarian cancer is the 5th leading cause of cancer death in women in the United States1and other western countries; about three quarters of those deaths are due to high-grade serous carcinoma (HGSC)2. Extrauterine high-grade serous carcinomas (ovary, fallopian tube, peritoneum) are aggressive t...
Chemotherapy Response Score (CRS): A comprehensive review of its prognostic and predictive value in High-Grade Serous Carcinoma (HGSC) Ovarian carcinoma, the second most common gynecological cancer in Western countries, is frequently diagnosed at advanced stages, necessitating complex treatment strategies....
Controversy about the cell of origin of high-grade serous carcinoma still exists. The presence of serous intraepithelial carcinoma (STIC) in the fallopian tube in the absence of invasive disease and the coexistence of STIC with high-grade serous carcinoma in sporadic as well as in hereditary HGSC...
The two most prevalent subtypes of epithelial ovarian carcinoma (EOC) are ovarian clear cell carcinoma (OCCC) and high-grade serous ovarian carcinoma (HGSC). Patients with OCCC have a poor prognosis than those with HGSC due to chemoresistance, implying t
The objective of the present study was to perform a quantitative analysis of cancer stem cell (CSC) marker expression in ovarian carcinoma effusions. The clinical role of SSEA1 in metastatic high-grade serous carcinoma (HGSC) was additionally analyzed. CD133, Nanog, SOX2, Oct3/4, SSEA1, and...
For the first time, we report a case of a primary high-grade serous carcinoma of the fallopian tube in a 69-yr-old woman with intraepithelial involvement of endocervical glands. The patient had a remote history of tubal ligation and no known personal or family history of breast or gynecologi...
Many high-grade serous carcinomas (HGSCs) of the pelvis are thought to originate in the distal portion of the fallopian tube. Serous tubal intra-epithelial carcinoma (STIC) lesions are the putative precursor to HGSC and identifiable in ~ 50% of advanc