Primary fallopian tube high-grade serous carcinoma (HGSCa) has historically been considered an uncommon neoplasm. Recent evidence, however, suggests that most extrauterine HGSCa arise within the fimbriae of the fallopian tube, via an intraepithelial precursor lesion known as serous tubal intraepithelial...
high-grade serous carcinoma (HGSC), usually arises from epithelium on the fallopian tube fimbriae, and not from the ovarian surface epithelium. We have developed Ovgp1-iCreER T2 mice in which the Ovgp1 promoter controls expression of tamoxifen-regulated Cre recombinase in oviductal epithelium-the ...
因此,理论上,总突变负担(TMB)应该能够确定患者对ICI的反应。一致地,ICI显示对于具有较高突变负荷的肿瘤类型(例如非小细胞肺癌和黑素瘤)更有效,这意味着有利的临床预后与产生新抗原以增强免疫根除的能力相关。然而,对于患有HGSOC的患者,TMB是否与其免疫原性平行以及TME中哪些方面确定特异性的免疫原性仍然不太清楚。 ...
High-grade serous ovarian carcinoma (HGSOC) is the most frequent type of ovarian cancer and has a poor outcome. It has been proposed that fallopian tube cancers may be precursors of HGSOC but evolutionary evidence for this hypothesis has been limited. Here, we perform whole-exome sequence and...
High-grade extrauterine serous carcinoma (HGSC) is an aggressive tumor with high rates of recurrence, frequent chemotherapy resistance, and overall 5-year survival of less than 50%. Beyond determining and confirming the diagnosis itself, pathologist review of histologic slides provides no prognostic or...
Chemotherapy Response Score (CRS): A comprehensive review of its prognostic and predictive value in High-Grade Serous Carcinoma (HGSC) Ovarian carcinoma, the second most common gynecological cancer in Western countries, is frequently diagnosed at advanced stages, necessitating complex treatment strategies....
High-grade serous ovarian carcinoma (HGSOC) is the most aggressive type of ovarian cancer, often diagnosed at advanced stages. Molecularly, HGSOC shows high degree of genomic instability associated with large number of genetic alterations. BRD4 is the 4t
The two most prevalent subtypes of epithelial ovarian carcinoma (EOC) are ovarian clear cell carcinoma (OCCC) and high-grade serous ovarian carcinoma (HGSC). Patients with OCCC have a poor prognosis than those with HGSC due to chemoresistance, implying the need for novel treatment target. In thi...
Many high-grade serous carcinomas (HGSCs) of the pelvis are thought to originate in the distal portion of the fallopian tube. Serous tubal intra-epithelial carcinoma (STIC) lesions are the putative precursor to HGSC and identifiable in ~ 50% of advanc