近日,一组来自意大利的研究团队在杂志Sciencetranslationalmedicine上发表了一篇题为“Genomic instability analysis in DNA from Papanicolaoutestprovides proof-of-principle early diagnosis of high-grade serous ovarian cancer”的文章。本研究的目的是为pDNA中体细胞拷贝数改变(SCNAs)的分析提供实验证据,并将其纳入命名...
peritoneal cancerpredictive biomarkerIn the era of personalized medicine, where transition from organ-based to individualized genetic diagnosis takes place, the tailoring of treatment in cancer becomes increasingly important. This is particularly true for high-grade, advanced FIGO stage serous adenocarcinomas...
海外直订Tumor Microenvironment High Grade Serous Ovarian Cancer 高级别级别浆液卵巢癌的肿瘤环境科普读物 683元 (包邮,需用券)价格:783元满600减20每300减40淘金币可抵3%满1600减50满300减5满1000减30海外直订The Tumor Microenvironment of High Grade Serous Ovarian Cancer 高级别浆液性卵巢癌的肿瘤微环境20...
Recent studies have suggested that the most common and lethal type of 'ovarian' cancer, i.e. high-grade serous carcinoma (HGSC), usually arises from epithelium on the fallopian tube fimbriae, and not from the ovarian surface epithelium. We have developed Ovgp1-iCreER T2 mice in which the ...
低级别浆液性卵巢癌(Low-grade serous ovarian cancer,简称LGSOC)是一种卵巢癌比较少见的亚型,癌细胞的生长速度较慢,细胞异型程度较低。相对于高级别浆液性卵巢癌(High-grade serous ovarian cancer),LGSOC的病情发展通常较缓慢,但复发风险很高,大约85%的患者会遭遇复发,而且会对化疗耐药。
Thus, "ovarian cancer" is also largely synonymous with "high-grade serous ovarian cancer (HGSC)." While significant tumor burden often involves the ovaries at the time of diagnosis, also typical is widespread metastatic disease involving the fallopian tubes, peritoneal surfaces, and omentum, ...
Keywords: ovarian cancer; molecular subtypes; diagnostic classifier; MALDI-IMS 1. Introduction High-grade serous ovarian cancer (HGSOC) is the most common histological sub- type of ovarian cancer to be diagnosed clinically. Due to a lack of adequate early-stage detection, HGSOC accounts for a ...
High grade serous ovarian carcinoma (HGSOC) is a highly heterogeneous disease that typically presents at an advanced, metastatic state. The multi-scale complexity of HGSOC is a major obstacle to predicting response to neoadjuvant chemotherapy (NACT) and
High-grade serous ovarian carcinoma (HGSOC) is the most frequent type of ovarian cancer and has a poor outcome. It has been proposed that fallopian tube cancers may be precursors of HGSOC but evolutionary evidence for this hypothesis has been limited. Here, we perform whole-exome sequence and...
High-grade serous carcinoma (HGSC) is the most prevalent and aggressive subtype of ovarian cancer. The large degree of clinical heterogeneity within HGSC has justified deviations from the traditional one-size-fits-all clinical management approach. However, the majority of HGSC patients still relapse ...