High-grade serous ovarian cancer3D model systemsSpheroidsPatient-derived organoidsEpithelial ovarian cancer (EOC) research has become more complex as researchers try to fully understand the metastatic process. Especially as we delve into the concept of tumour dormancy, where cells transition between ...
Ovarian cancer is the 5th leading cause of cancer death in women in the United States1and other western countries; about three quarters of those deaths are due to high-grade serous carcinoma (HGSC)2. Extrauterine high-grade serous carcinomas (ovary, fallopian tube, peritoneum) are aggressive t...
While TP53 mutation is widely considered to be a defining feature of tubo-ovarian high-grade serous carcinoma (HGSC), rare TP53-mutation-negative cases have been reported. To gain further insight into this rare subset, a retrospective review was conducte
The two most prevalent subtypes of epithelial ovarian carcinoma (EOC) are ovarian clear cell carcinoma (OCCC) and high-grade serous ovarian carcinoma (HGSC). Patients with OCCC have a poor prognosis than those with HGSC due to chemoresistance, implying t
- 《Journal of Pathology Journal of the Pathological Society of Great Britain & Ireland》 被引量: 15发表: 2017年 High-grade serous carcinomas arise in the mouse oviduct via defects linked to the human disease (vol 243, pg16, 2017) Cho, High-grade serous carcinomas arise in the mouse ...
Molecular pathogenesis of high-grade serous ovarian carcinoma (HG-SOC) is poorly understood. Recent recognition of HG-SOC precursor lesions, defined as ser... Z Liu,J Liu,MF Segura,... - 《Journal of Pathology》 被引量: 213发表: 2012年 Origin and molecular pathogenesis of ovarian high-grad...
High-grade serous ovarian carcinoma (HGSOC) is the most aggressive type of ovarian cancer, often diagnosed at advanced stages. Molecularly, HGSOC shows high degree of genomic instability associated with large number of genetic alterations. BRD4 is the 4t
High-grade serous carcinoma (HGSC) is the most prevalent and aggressive subtype of ovarian cancer. The large degree of clinical heterogeneity within HGSC has justified deviations from the traditional one-size-fits-all clinical management approach. Howeve
High-grade serous ovarian carcinoma (HGSOC) is the most frequent type of ovarian cancer and has a poor outcome. It has been proposed that fallopian tube cancers may be precursors of HGSOC but evolutionary evidence for this hypothesis has been limited. Here, we perform whole-exome sequence and...
The cell-of-origin of high grade serous ovarian carcinoma (HGSOC) remains controversial, with fallopian tube epithelium (FTE) and ovarian surface epithelium (OSE) both considered candidates. Here, by using genetically engineered mouse models and organoids, we assessed the tumor-forming properties of...