It is commonly believed that prostate cancer patients with very high prostate-specific antigen(PSA) levels are unlikely to benefit from definitive local treatment,and patients with very high PSA are often underrepresented in randomized clinical trials.A registry-based analysis of 6449 patients without ...
Acute myocardial infarction without cardiogenic shock does not affect serum prostate specific antigen levels: A case control study The prostate-specific antigen (PSA) serum level is of utmost diagnostic importance as probability of prostate cancer (PCa) increases with increasing serum ... ztekin,C....
Systemic metabolic alterations associated with increased consumption of saturated fat and obesity are linked with increased risk of prostate cancer progression and mortality, but the molecular underpinnings of this association are poorly understood. Here, we demonstrate in a murine prostate cancer model, t...
Cancer immunotherapies such as bispecific T-cell engagers have seen limited adoption in prostate cancer (PC), possibly due to differing levels of cancer receptor expression and effector T-cell infiltration between patients and inherent defects in T-cell engager design. Methods CD8+ T-cell infiltration...
Prostate cancer diagnosis among men with isolated high-grade intraepithelial neoplasia enrolled onto a 3-year prospective phase III clinical trial of oral ... Purpose;Prostate cancer (PCa) prevention remains an appealing strategy for the reduction of overtreatment and secondary adverse effects. We evalu...
Diagram of Study Cohort View LargeDownload M1 indicates bone metastases; NCCN, National Comprehensive Cancer Network; PSA, prostate-specific antigen. Figure 2. Overall Survival of Patients Treated at High vs Low Average Cumulative Facility Radiation Volume Centers View LargeDownload Unadjusted (A) and ...
Most of the reason for the 2012 USPSTF recommendation against PSA testing was owing to the detection and treatment of LG PCA, a tumor that is often indolent. With the PSA screening pendulum swinging away from testing, there is a risk that successes in reducing prostate cancer mortality will ...
Following treatment completion, patients were followed with mostly lab assessment until PSA progression, at which point, treatment was per investigator discretion.” Breast Cancer Overall survival (OS) results from the phase III TROPiCS-02 study of sacituzumab govitecan (SG) vs treatment of ...
4Department of Oncological Surgery, The Chaim Sheba Medical Center, Tel-Hashomer, Israel; 5Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel While genetic factors clearly play a role in conferring breast cancer risk, the contribution of ATM gene mutations to breast cancer is stil...
HGPIN alone does not result in abnormal digital rectal examination nor elevated serum PSA. It may appear as a hypoechoic lesion on sonography, indistinguishable from pros- tate carcinoma. The clinical importance of a HGPIN diagnosis in prostate biopsies is the risk of cancer detection in subsequent...